Noncoding RNAs in Apicomplexan Parasites: An Update

Yiran Li, Rodrigo P. Baptista, Jessica C. Kissinger

Research output: Contribution to journalReview articlepeer-review

Abstract

Recent breakthroughs in high-throughput technologies, transcriptomics, and advances in our understanding of gene regulatory networks have enhanced our perspective on the complex interplay between parasite and host. Noncoding RNA molecules have been implicated in critical roles covering a broad range of biological processes in the Apicomplexa. Processes that are affected range from parasite development to host–parasite interactions and include interactions with epigenetic machinery and other regulatory factors. Here we review recent progress involving noncoding RNAs and their functions in the Apicomplexa, with a focus on three parasites: Plasmodium, Toxoplasma, and Cryptosporidium. We discuss the limitations and challenges of current methods applied to apicomplexan noncoding RNA study and discuss future directions in this exciting field.

Original languageEnglish (US)
Pages (from-to)835-849
Number of pages15
JournalTrends in Parasitology
Volume36
Issue number10
DOIs
StatePublished - Oct 2020

Keywords

  • Apicomplexa
  • lncRNA
  • ncRNA
  • sncRNA

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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