Non-invasive vascular modulography: An inverse problem method for imaging the local elasticity of atherosclerotic carotid plaques

Jonathan Porée, Damien Garcia, Boris Chayer, Gilles Soulez, Jacques Ohayon, Guy Cloutier

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Quantifying biomechanical properties of atherosclerotic plaques may help preventing strokes. Non-invasive vascular elastography (NIVE) in superficial carotid arteries has the potential to assess such properties and to discriminate plaque components (e.g., fibrosis, lipid and calcium) through elastograms (i.e., spatial strain distribution). However, the elasticity and morphology of the vessel wall, cannot be assessed directly from strain maps since the stress distribution remains unknown. In this study, we describe an unsupervised inverse problem for elasticity mapping (non invasive vascular modulography), which is capable of reconstructing a heterogeneous Young's modulus distribution of a plaque. High resolution elastograms were computed from ultrasound compounded plane wave images using the constrained lagrangian speckle model estimator (constrained LSME). Von mises strain maps were combined with a stress map, evaluated using a parametric finite element model (PFEM), and used to highlight mechanical heterogeneities and compute Young modulus maps (Modulograms).

Original languageEnglish (US)
Title of host publicationIEEE International Ultrasonics Symposium, IUS
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1798-1801
Number of pages4
ISBN (Electronic)9781479970490
DOIs
StatePublished - Oct 20 2014
Event2014 IEEE International Ultrasonics Symposium, IUS 2014 - Chicago, United States
Duration: Sep 3 2014Sep 6 2014

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

Conference2014 IEEE International Ultrasonics Symposium, IUS 2014
CountryUnited States
CityChicago
Period9/3/149/6/14

Keywords

  • circular waves
  • diverging waves
  • Elastography
  • modulography
  • ultrafast ultrasound

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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