Non-Invasive Imaging of Normalized Solid Stress in Cancers in Vivo

Md Tauhidul Islam, Ennio Tasciotti, Raffaella Righetti

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The solid stress (SSg) that develops inside a cancer is an important marker of cancer's growth, invasion and metastasis. Currently, there are no non-invasive methods to image SSg inside tumors. In this paper, we develop a new, non-invasive and cost-effective imaging method to assess SSg inside tumors that uses ultrasound poroelastography. Center to the proposed method is a novel analytical model, which demonstrates that SSg and the compression-induced stress (SSc) that generates inside the cancer in a poroelastography experiment have the same spatial distribution. To show the clinical feasibility of the proposed technique, we imaged and analyzed the normalized SSg inside treated and untreated human breast cancers in a small animal model. Given the clinical significance of assessing SSg in cancers and the advantages of the proposed ultrasonic methods, our technique could have a great impact on cancer diagnosis, prognosis and treatment methods.

Original languageEnglish (US)
Article number8836122
JournalIEEE Journal of Translational Engineering in Health and Medicine
Volume7
DOIs
StatePublished - 2019

Keywords

  • Cancer imaging
  • cancer biomechanics
  • elastography
  • interstitial fluid pressure
  • microenvironment
  • oncophysics
  • poroelastography
  • solid stress

ASJC Scopus subject areas

  • Biomedical Engineering

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