Non-Hodgkin lymphomas of mice

Mitsuo Hori; Shao Xiang; Chen Feng Qi; Sisir K. Chattopadhyay; Torgny N. Fredrickson; Janet W. Hartley; Alexander L. Kovalchuk; Georg W. Bornkamm; Siegfried Janz; Neal G. Copeland; Nancy A. Jenkins; Jerrold M. Ward; Herbert C. Morse

doi:10.1006/bcmd.2000.0375

Non-Hodgkin lymphomas of mice

Mitsuo Hori, Shao Xiang, Chen Feng Qi, Sisir K. Chattopadhyay, Torgny N. Fredrickson, Janet W. Hartley, Alexander L. Kovalchuk, Georg W. Bornkamm, Siegfried Janz, Neal G. Copeland, Nancy A. Jenkins, Jerrold M. Ward, Herbert C. Morse

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Studies of lymphoid neoplasms occurring in normal or genetically engineered mice have revealed parallels and differences to non-Hodgkin lymphomas (NHL) of humans. Some mouse lymphomas have strong histologic similarities to the human NHL subsets including precursor B- and T-cell lymphoblastic, small lymphocytic, splenic marginal zone, and diffuse large-cell B-cell lymphomas (DLCL); whether molecular parallels also exist is under study. Others mouse types such as sIg⁺ lymphoblastic B-cell lymphoma have no histologic equivalent in human NHL even though they share molecular deregulation of BCL6 with human DLCL. Finally, Burkitt lymphoma does not appear to occur naturally in mice, but it can be induced with appropriately engineered transgenes.

Original language	English (US)
Pages (from-to)	217-222
Number of pages	6
Journal	Blood Cells, Molecules, and Diseases
Volume	27
Issue number	1
DOIs	https://doi.org/10.1006/bcmd.2000.0375
State	Published - 2001

Keywords

BCL6
Burkitt lymphoma
Mouse lymphoma
MYC
non-Hodgkin lymphoma

ASJC Scopus subject areas

Molecular Biology
Molecular Medicine
Hematology

Access to Document

10.1006/bcmd.2000.0375

Cite this

@article{5e13a426d58541fa8a3f42f08fa5efc4,

title = "Non-Hodgkin lymphomas of mice",

abstract = "Studies of lymphoid neoplasms occurring in normal or genetically engineered mice have revealed parallels and differences to non-Hodgkin lymphomas (NHL) of humans. Some mouse lymphomas have strong histologic similarities to the human NHL subsets including precursor B- and T-cell lymphoblastic, small lymphocytic, splenic marginal zone, and diffuse large-cell B-cell lymphomas (DLCL); whether molecular parallels also exist is under study. Others mouse types such as sIg+ lymphoblastic B-cell lymphoma have no histologic equivalent in human NHL even though they share molecular deregulation of BCL6 with human DLCL. Finally, Burkitt lymphoma does not appear to occur naturally in mice, but it can be induced with appropriately engineered transgenes.",

keywords = "BCL6, Burkitt lymphoma, Mouse lymphoma, MYC, non-Hodgkin lymphoma",

author = "Mitsuo Hori and Shao Xiang and Qi, {Chen Feng} and Chattopadhyay, {Sisir K.} and Fredrickson, {Torgny N.} and Hartley, {Janet W.} and Kovalchuk, {Alexander L.} and Bornkamm, {Georg W.} and Siegfried Janz and Copeland, {Neal G.} and Jenkins, {Nancy A.} and Ward, {Jerrold M.} and Morse, {Herbert C.}",

note = "Funding Information: This work has been supported by grants to G.W.B. from Deutsche Forschungsgemeinschaft and Deutsche Krebshilfe. We thank Brenda Rae Marshall for excellent editorial assistance. This paper was presented at a Focused Workshop on Animal Models of Leukemia and Lymphoma jointly sponsored by the Leukemia & Lymphoma Society and the Mouse Models of Human Cancer Consortium of the National Cancer Institute on September 19 –20, 2000. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2001",

doi = "10.1006/bcmd.2000.0375",

language = "English (US)",

volume = "27",

pages = "217--222",

journal = "Blood Cells, Molecules, and Diseases",

issn = "1079-9796",

publisher = "Academic Press",

number = "1",

}

TY - JOUR

T1 - Non-Hodgkin lymphomas of mice

AU - Hori, Mitsuo

AU - Xiang, Shao

AU - Qi, Chen Feng

AU - Chattopadhyay, Sisir K.

AU - Fredrickson, Torgny N.

AU - Hartley, Janet W.

AU - Kovalchuk, Alexander L.

AU - Bornkamm, Georg W.

AU - Janz, Siegfried

AU - Copeland, Neal G.

AU - Jenkins, Nancy A.

AU - Ward, Jerrold M.

AU - Morse, Herbert C.

N1 - Funding Information: This work has been supported by grants to G.W.B. from Deutsche Forschungsgemeinschaft and Deutsche Krebshilfe. We thank Brenda Rae Marshall for excellent editorial assistance. This paper was presented at a Focused Workshop on Animal Models of Leukemia and Lymphoma jointly sponsored by the Leukemia & Lymphoma Society and the Mouse Models of Human Cancer Consortium of the National Cancer Institute on September 19 –20, 2000. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2001

Y1 - 2001

N2 - Studies of lymphoid neoplasms occurring in normal or genetically engineered mice have revealed parallels and differences to non-Hodgkin lymphomas (NHL) of humans. Some mouse lymphomas have strong histologic similarities to the human NHL subsets including precursor B- and T-cell lymphoblastic, small lymphocytic, splenic marginal zone, and diffuse large-cell B-cell lymphomas (DLCL); whether molecular parallels also exist is under study. Others mouse types such as sIg+ lymphoblastic B-cell lymphoma have no histologic equivalent in human NHL even though they share molecular deregulation of BCL6 with human DLCL. Finally, Burkitt lymphoma does not appear to occur naturally in mice, but it can be induced with appropriately engineered transgenes.

AB - Studies of lymphoid neoplasms occurring in normal or genetically engineered mice have revealed parallels and differences to non-Hodgkin lymphomas (NHL) of humans. Some mouse lymphomas have strong histologic similarities to the human NHL subsets including precursor B- and T-cell lymphoblastic, small lymphocytic, splenic marginal zone, and diffuse large-cell B-cell lymphomas (DLCL); whether molecular parallels also exist is under study. Others mouse types such as sIg+ lymphoblastic B-cell lymphoma have no histologic equivalent in human NHL even though they share molecular deregulation of BCL6 with human DLCL. Finally, Burkitt lymphoma does not appear to occur naturally in mice, but it can be induced with appropriately engineered transgenes.

KW - BCL6

KW - Burkitt lymphoma

KW - Mouse lymphoma

KW - MYC

KW - non-Hodgkin lymphoma

UR - http://www.scopus.com/inward/record.url?scp=0035051756&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035051756&partnerID=8YFLogxK

U2 - 10.1006/bcmd.2000.0375

DO - 10.1006/bcmd.2000.0375

M3 - Article

C2 - 11358382

AN - SCOPUS:0035051756

VL - 27

SP - 217

EP - 222

JO - Blood Cells, Molecules, and Diseases

JF - Blood Cells, Molecules, and Diseases

SN - 1079-9796

IS - 1

ER -

Non-Hodgkin lymphomas of mice

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this