Abstract
Interleukin (IL)-12 plays a pivotal role in cell-mediated immunity to Mycobacterium tuberculosis infection. We tested the association between a biallelic single-nucleotide polymorphism in the 3′ untranslated region (UTR) of IL-12B and human susceptibility to tuberculosis (TB), in a population-based case-control study of adult patients with TB from 2 ethnicities, African American and white, and in a family-based transmission/disequilibrium study of 60 informative families with at least 1 pediatric patient with TB and 1 heterozygous parent. Our results suggest that IL-12B 3′ UTR has no effect or has a negligible effect on human susceptibility to TB.
Original language | English (US) |
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Pages (from-to) | 1116-1118 |
Number of pages | 3 |
Journal | Journal of Infectious Diseases |
Volume | 188 |
Issue number | 8 |
DOIs | |
State | Published - Oct 15 2003 |
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases