No Evidence for Association between the Polymorphism in the 3′ Untranslated Region of Interleukin-12B and Human Susceptibility to Tuberculosis

Xin Ma, Robert A. Reich, Omar Gonzalez, Xi Pan, Amanda K. Fothergill, Jeffery R. Starke, Larry D. Teeter, James M. Musser, Edward A. Graviss

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Interleukin (IL)-12 plays a pivotal role in cell-mediated immunity to Mycobacterium tuberculosis infection. We tested the association between a biallelic single-nucleotide polymorphism in the 3′ untranslated region (UTR) of IL-12B and human susceptibility to tuberculosis (TB), in a population-based case-control study of adult patients with TB from 2 ethnicities, African American and white, and in a family-based transmission/disequilibrium study of 60 informative families with at least 1 pediatric patient with TB and 1 heterozygous parent. Our results suggest that IL-12B 3′ UTR has no effect or has a negligible effect on human susceptibility to TB.

Original languageEnglish (US)
Pages (from-to)1116-1118
Number of pages3
JournalJournal of Infectious Diseases
Volume188
Issue number8
DOIs
StatePublished - Oct 15 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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