No Evidence for Association between the Polymorphism in the 3′ Untranslated Region of Interleukin-12B and Human Susceptibility to Tuberculosis

Xin Ma; Robert A. Reich; Omar Gonzalez; Xi Pan; Amanda K. Fothergill; Jeffery R. Starke; Larry D. Teeter; James M. Musser; Edward A. Graviss

doi:10.1086/378674

No Evidence for Association between the Polymorphism in the 3′ Untranslated Region of Interleukin-12B and Human Susceptibility to Tuberculosis

Xin Ma, Robert A. Reich, Omar Gonzalez, Xi Pan, Amanda K. Fothergill, Jeffery R. Starke, Larry D. Teeter, James M. Musser, Edward A. Graviss

Research output: Contribution to journal › Article

34 Scopus citations

Abstract

Interleukin (IL)-12 plays a pivotal role in cell-mediated immunity to Mycobacterium tuberculosis infection. We tested the association between a biallelic single-nucleotide polymorphism in the 3′ untranslated region (UTR) of IL-12B and human susceptibility to tuberculosis (TB), in a population-based case-control study of adult patients with TB from 2 ethnicities, African American and white, and in a family-based transmission/disequilibrium study of 60 informative families with at least 1 pediatric patient with TB and 1 heterozygous parent. Our results suggest that IL-12B 3′ UTR has no effect or has a negligible effect on human susceptibility to TB.

Original language	English (US)
Pages (from-to)	1116-1118
Number of pages	3
Journal	Journal of Infectious Diseases
Volume	188
Issue number	8
DOIs	https://doi.org/10.1086/378674
State	Published - Oct 15 2003

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

Access to Document

10.1086/378674

Fingerprint Dive into the research topics of 'No Evidence for Association between the Polymorphism in the 3′ Untranslated Region of Interleukin-12B and Human Susceptibility to Tuberculosis'. Together they form a unique fingerprint.

Cite this

No Evidence for Association between the Polymorphism in the 3′ Untranslated Region of Interleukin-12B and Human Susceptibility to Tuberculosis. / Ma, Xin; Reich, Robert A.; Gonzalez, Omar; Pan, Xi; Fothergill, Amanda K.; Starke, Jeffery R.; Teeter, Larry D.; Musser, James M.; Graviss, Edward A.

In: Journal of Infectious Diseases, Vol. 188, No. 8, 15.10.2003, p. 1116-1118.

Research output: Contribution to journal › Article

Ma, Xin ; Reich, Robert A. ; Gonzalez, Omar ; Pan, Xi ; Fothergill, Amanda K. ; Starke, Jeffery R. ; Teeter, Larry D. ; Musser, James M. ; Graviss, Edward A. / No Evidence for Association between the Polymorphism in the 3′ Untranslated Region of Interleukin-12B and Human Susceptibility to Tuberculosis. In: Journal of Infectious Diseases. 2003 ; Vol. 188, No. 8. pp. 1116-1118.

@article{b60f29047d3748bdbc65ee51dc2f4cf2,

title = "No Evidence for Association between the Polymorphism in the 3′ Untranslated Region of Interleukin-12B and Human Susceptibility to Tuberculosis",

abstract = "Interleukin (IL)-12 plays a pivotal role in cell-mediated immunity to Mycobacterium tuberculosis infection. We tested the association between a biallelic single-nucleotide polymorphism in the 3′ untranslated region (UTR) of IL-12B and human susceptibility to tuberculosis (TB), in a population-based case-control study of adult patients with TB from 2 ethnicities, African American and white, and in a family-based transmission/disequilibrium study of 60 informative families with at least 1 pediatric patient with TB and 1 heterozygous parent. Our results suggest that IL-12B 3′ UTR has no effect or has a negligible effect on human susceptibility to TB.",

author = "Xin Ma and Reich, {Robert A.} and Omar Gonzalez and Xi Pan and Fothergill, {Amanda K.} and Starke, {Jeffery R.} and Teeter, {Larry D.} and Musser, {James M.} and Graviss, {Edward A.}",

year = "2003",

month = oct,

day = "15",

doi = "10.1086/378674",

language = "English (US)",

volume = "188",

pages = "1116--1118",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "8",

}

TY - JOUR

T1 - No Evidence for Association between the Polymorphism in the 3′ Untranslated Region of Interleukin-12B and Human Susceptibility to Tuberculosis

AU - Ma, Xin

AU - Reich, Robert A.

AU - Gonzalez, Omar

AU - Pan, Xi

AU - Fothergill, Amanda K.

AU - Starke, Jeffery R.

AU - Teeter, Larry D.

AU - Musser, James M.

AU - Graviss, Edward A.

PY - 2003/10/15

Y1 - 2003/10/15

N2 - Interleukin (IL)-12 plays a pivotal role in cell-mediated immunity to Mycobacterium tuberculosis infection. We tested the association between a biallelic single-nucleotide polymorphism in the 3′ untranslated region (UTR) of IL-12B and human susceptibility to tuberculosis (TB), in a population-based case-control study of adult patients with TB from 2 ethnicities, African American and white, and in a family-based transmission/disequilibrium study of 60 informative families with at least 1 pediatric patient with TB and 1 heterozygous parent. Our results suggest that IL-12B 3′ UTR has no effect or has a negligible effect on human susceptibility to TB.

AB - Interleukin (IL)-12 plays a pivotal role in cell-mediated immunity to Mycobacterium tuberculosis infection. We tested the association between a biallelic single-nucleotide polymorphism in the 3′ untranslated region (UTR) of IL-12B and human susceptibility to tuberculosis (TB), in a population-based case-control study of adult patients with TB from 2 ethnicities, African American and white, and in a family-based transmission/disequilibrium study of 60 informative families with at least 1 pediatric patient with TB and 1 heterozygous parent. Our results suggest that IL-12B 3′ UTR has no effect or has a negligible effect on human susceptibility to TB.

UR - http://www.scopus.com/inward/record.url?scp=0242269884&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242269884&partnerID=8YFLogxK

U2 - 10.1086/378674

DO - 10.1086/378674

M3 - Article

C2 - 14551880

AN - SCOPUS:0242269884

VL - 188

SP - 1116

EP - 1118

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 8

ER -