TY - JOUR
T1 - No Evidence for Association between the Polymorphism in the 3′ Untranslated Region of Interleukin-12B and Human Susceptibility to Tuberculosis
AU - Ma, Xin
AU - Reich, Robert A.
AU - Gonzalez, Omar
AU - Pan, Xi
AU - Fothergill, Amanda K.
AU - Starke, Jeffery R.
AU - Teeter, Larry D.
AU - Musser, James M.
AU - Graviss, Edward A.
N1 - Funding Information:
Received 17 March 2003; accepted 30 April 2003; electronically published 26 September 2003. Financial support: National Institute of Allergy and Infectious Diseases, National Institutes of Health (contracts N01-AO-02738 and AI 41168). The novel single-nucleotide polymorphism (SNP) reported in this study has been deposited in the SNP database of the National Center for Biotechnology Information (assay identification number [ss#] 4480616). Reprints or correspondence: Dr. Edward A. Graviss, Dept. of Pathology (209E), Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030 ([email protected]).
PY - 2003/10/15
Y1 - 2003/10/15
N2 - Interleukin (IL)-12 plays a pivotal role in cell-mediated immunity to Mycobacterium tuberculosis infection. We tested the association between a biallelic single-nucleotide polymorphism in the 3′ untranslated region (UTR) of IL-12B and human susceptibility to tuberculosis (TB), in a population-based case-control study of adult patients with TB from 2 ethnicities, African American and white, and in a family-based transmission/disequilibrium study of 60 informative families with at least 1 pediatric patient with TB and 1 heterozygous parent. Our results suggest that IL-12B 3′ UTR has no effect or has a negligible effect on human susceptibility to TB.
AB - Interleukin (IL)-12 plays a pivotal role in cell-mediated immunity to Mycobacterium tuberculosis infection. We tested the association between a biallelic single-nucleotide polymorphism in the 3′ untranslated region (UTR) of IL-12B and human susceptibility to tuberculosis (TB), in a population-based case-control study of adult patients with TB from 2 ethnicities, African American and white, and in a family-based transmission/disequilibrium study of 60 informative families with at least 1 pediatric patient with TB and 1 heterozygous parent. Our results suggest that IL-12B 3′ UTR has no effect or has a negligible effect on human susceptibility to TB.
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U2 - 10.1086/378674
DO - 10.1086/378674
M3 - Article
C2 - 14551880
AN - SCOPUS:0242269884
SN - 0022-1899
VL - 188
SP - 1116
EP - 1118
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 8
ER -