No association between the +874T/A single nucleotide polymorphism in the IFN-γ gene and susceptibility to TB

A. Moran; X. Ma; R. A. Reich; Edward A. Graviss

No association between the +874T/A single nucleotide polymorphism in the IFN-γ gene and susceptibility to TB

A. Moran, X. Ma, R. A. Reich, Edward A. Graviss

Research output: Contribution to journal › Article

Abstract

A single nucleotide polymorphism (SNP), +874T/A, in the first intron of the interferon-gamma (IFN-γ) gene, has presented associations with human susceptibility to tuberculosis (TB) in some ethnic populations, but not in others. In this population-based case-control study with adult TB patients from Houston, Texas, we found no significant differences of +874T/A genotypic frequencies between cases and ethnically-matched controls or between advanced forms of TB disease (extra-pulmonary involvement or presence of cavitary disease) and pulmonary TB. Given possible sample size limitations, our results suggest that the IFN-γ +874T/A mutation has no association with TB susceptibility or TB disease severity.

Original language	English (US)
Pages (from-to)	113-115
Number of pages	3
Journal	International Journal of Tuberculosis and Lung Disease
Volume	11
Issue number	1
State	Published - Jan 1 2007

Keywords

Cavitary
Extra-pulmonary
IFN-γ
Tuberculosis

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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title = "No association between the +874T/A single nucleotide polymorphism in the IFN-γ gene and susceptibility to TB",

abstract = "A single nucleotide polymorphism (SNP), +874T/A, in the first intron of the interferon-gamma (IFN-γ) gene, has presented associations with human susceptibility to tuberculosis (TB) in some ethnic populations, but not in others. In this population-based case-control study with adult TB patients from Houston, Texas, we found no significant differences of +874T/A genotypic frequencies between cases and ethnically-matched controls or between advanced forms of TB disease (extra-pulmonary involvement or presence of cavitary disease) and pulmonary TB. Given possible sample size limitations, our results suggest that the IFN-γ +874T/A mutation has no association with TB susceptibility or TB disease severity.",

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AU - Moran, A.

AU - Ma, X.

AU - Reich, R. A.

AU - Graviss, Edward A.

PY - 2007/1/1

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N2 - A single nucleotide polymorphism (SNP), +874T/A, in the first intron of the interferon-gamma (IFN-γ) gene, has presented associations with human susceptibility to tuberculosis (TB) in some ethnic populations, but not in others. In this population-based case-control study with adult TB patients from Houston, Texas, we found no significant differences of +874T/A genotypic frequencies between cases and ethnically-matched controls or between advanced forms of TB disease (extra-pulmonary involvement or presence of cavitary disease) and pulmonary TB. Given possible sample size limitations, our results suggest that the IFN-γ +874T/A mutation has no association with TB susceptibility or TB disease severity.

AB - A single nucleotide polymorphism (SNP), +874T/A, in the first intron of the interferon-gamma (IFN-γ) gene, has presented associations with human susceptibility to tuberculosis (TB) in some ethnic populations, but not in others. In this population-based case-control study with adult TB patients from Houston, Texas, we found no significant differences of +874T/A genotypic frequencies between cases and ethnically-matched controls or between advanced forms of TB disease (extra-pulmonary involvement or presence of cavitary disease) and pulmonary TB. Given possible sample size limitations, our results suggest that the IFN-γ +874T/A mutation has no association with TB susceptibility or TB disease severity.

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KW - Tuberculosis

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