No association between the +874T/A single nucleotide polymorphism in the IFN-γ gene and susceptibility to TB

A. Moran, X. Ma, R. A. Reich, Edward A. Graviss

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

A single nucleotide polymorphism (SNP), +874T/A, in the first intron of the interferon-gamma (IFN-γ) gene, has presented associations with human susceptibility to tuberculosis (TB) in some ethnic populations, but not in others. In this population-based case-control study with adult TB patients from Houston, Texas, we found no significant differences of +874T/A genotypic frequencies between cases and ethnically-matched controls or between advanced forms of TB disease (extra-pulmonary involvement or presence of cavitary disease) and pulmonary TB. Given possible sample size limitations, our results suggest that the IFN-γ +874T/A mutation has no association with TB susceptibility or TB disease severity.

Original languageEnglish (US)
Pages (from-to)113-115
Number of pages3
JournalInternational Journal of Tuberculosis and Lung Disease
Volume11
Issue number1
StatePublished - Jan 1 2007

Keywords

  • Cavitary
  • Extra-pulmonary
  • IFN-γ
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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