Abstract
Purpose: To report two patients with progressive optic pathway gliomas who had reversible visual loss after treatment with nitrosourea-based chemotherapy. Design: Retrospective case series. Results: Two patients with optic pathway gliomas and progressive visual field loss were treated with nitrosourea-based chemotherapy consisting of 6-thioguanine, procarbazine, 1-(2-chloroethyl)-3- cyclohexyl-1-nitrosourea (CCNU), and vincristine (TPCV). Both patients experienced dramatic and sustained visual improvement after treatment. Conclusion: Patients with progressive optic pathway gliomas may benefit from initial therapy with nitrosourea-based chemotherapy. This treatment might delay or avoid the need for radiation therapy and its associated side effects, especially in younger aged children.
Original language | English (US) |
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Pages (from-to) | 107-115 |
Number of pages | 9 |
Journal | Neuro-Ophthalmology |
Volume | 28 |
Issue number | 2 |
DOIs | |
State | Published - Sep 2002 |
Keywords
- Nitrosourea chemotherapy
- Optic pathway glioma
ASJC Scopus subject areas
- Ophthalmology
- Clinical Neurology