Nitrosourea-based chemotherapy in optic pathway glioma with progressive visual loss

Andrew G. Lee, M. Sue O'Dorisio

Research output: Contribution to journalArticlepeer-review


Purpose: To report two patients with progressive optic pathway gliomas who had reversible visual loss after treatment with nitrosourea-based chemotherapy. Design: Retrospective case series. Results: Two patients with optic pathway gliomas and progressive visual field loss were treated with nitrosourea-based chemotherapy consisting of 6-thioguanine, procarbazine, 1-(2-chloroethyl)-3- cyclohexyl-1-nitrosourea (CCNU), and vincristine (TPCV). Both patients experienced dramatic and sustained visual improvement after treatment. Conclusion: Patients with progressive optic pathway gliomas may benefit from initial therapy with nitrosourea-based chemotherapy. This treatment might delay or avoid the need for radiation therapy and its associated side effects, especially in younger aged children.

Original languageEnglish (US)
Pages (from-to)107-115
Number of pages9
Issue number2
StatePublished - Sep 2002


  • Nitrosourea chemotherapy
  • Optic pathway glioma

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology


Dive into the research topics of 'Nitrosourea-based chemotherapy in optic pathway glioma with progressive visual loss'. Together they form a unique fingerprint.

Cite this