Nitric oxide-generating L-cysteine-grafted graphene film as a blood-contacting biomaterial

Zhen Du; Ruixia Dou; Mian Zu; Xueying Liu; Wenyan Yin; Yuliang Zhao; Jingbo Chen; Liang Yan; Zhanjun Gu

doi:10.1039/c6bm00074f

Nitric oxide-generating L-cysteine-grafted graphene film as a blood-contacting biomaterial

Zhen Du, Ruixia Dou, Mian Zu, Xueying Liu, Wenyan Yin, Yuliang Zhao, Jingbo Chen, Liang Yan, Zhanjun Gu

Houston Methodist

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

By using polyethylenimine molecules as the linker, l-cysteine was immobilized onto graphene nanosheets, endowing the biocompatible l-cysteine-functionalized graphene film with the ability for catalytic decomposition of exogenous or endogenous donors to generate nitric oxide, and thus inhibiting the platelet activation and aggregation and reducing platelet adhesion.

Original language	English (US)
Pages (from-to)	938-942
Number of pages	5
Journal	Biomaterials Science
Volume	4
Issue number	6
DOIs	https://doi.org/10.1039/c6bm00074f
State	Published - Jun 2016

ASJC Scopus subject areas

Biomedical Engineering
General Materials Science

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title = "Nitric oxide-generating L-cysteine-grafted graphene film as a blood-contacting biomaterial",

abstract = "By using polyethylenimine molecules as the linker, l-cysteine was immobilized onto graphene nanosheets, endowing the biocompatible l-cysteine-functionalized graphene film with the ability for catalytic decomposition of exogenous or endogenous donors to generate nitric oxide, and thus inhibiting the platelet activation and aggregation and reducing platelet adhesion.",

author = "Zhen Du and Ruixia Dou and Mian Zu and Xueying Liu and Wenyan Yin and Yuliang Zhao and Jingbo Chen and Liang Yan and Zhanjun Gu",

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year = "2016",

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T1 - Nitric oxide-generating L-cysteine-grafted graphene film as a blood-contacting biomaterial

AU - Du, Zhen

AU - Dou, Ruixia

AU - Zu, Mian

AU - Liu, Xueying

AU - Yin, Wenyan

AU - Zhao, Yuliang

AU - Chen, Jingbo

AU - Yan, Liang

AU - Gu, Zhanjun

PY - 2016/6

Y1 - 2016/6

N2 - By using polyethylenimine molecules as the linker, l-cysteine was immobilized onto graphene nanosheets, endowing the biocompatible l-cysteine-functionalized graphene film with the ability for catalytic decomposition of exogenous or endogenous donors to generate nitric oxide, and thus inhibiting the platelet activation and aggregation and reducing platelet adhesion.

AB - By using polyethylenimine molecules as the linker, l-cysteine was immobilized onto graphene nanosheets, endowing the biocompatible l-cysteine-functionalized graphene film with the ability for catalytic decomposition of exogenous or endogenous donors to generate nitric oxide, and thus inhibiting the platelet activation and aggregation and reducing platelet adhesion.

UR - https://www.scopus.com/pages/publications/84971222635

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U2 - 10.1039/c6bm00074f

DO - 10.1039/c6bm00074f

M3 - Article

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AN - SCOPUS:84971222635

SN - 2047-4830

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JO - Biomaterials Science

JF - Biomaterials Science

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ER -

Nitric oxide-generating L-cysteine-grafted graphene film as a blood-contacting biomaterial

Abstract

ASJC Scopus subject areas

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