Nitric oxide-cyclic GMP signaling in stem cell differentiation

Kalpana Mujoo, Joshua S. Krumenacker, Ferid Murad

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations


The nitric oxide-cyclic GMP (NO-cGMP) pathway mediates important physiological functions associated with various integrative body systems including the cardiovascular and nervous systems. Furthermore, NO regulates cell growth, survival, apoptosis, proliferation, and differentiation at the cellular level. To understand the significance of the NO-cGMP pathway in development and differentiation, studies have been conducted both in developing embryos and in stem cells. Manipulation of the NO-cGMP pathway, by employing activators and inhibitors as pharmacological probes, and genetic manipulation of NO signaling components have implicated the involvement of this pathway in the regulation of stem cell differentiation. This review focuses on some of the work pertaining to the role of NO-cGMP in the differentiation of stem cells into cells of various lineages, particularly into myocardial cells, and in stem cell-based therapy.

Original languageEnglish (US)
Pages (from-to)2150-2157
Number of pages8
JournalFree Radical Biology and Medicine
Issue number12
StatePublished - Dec 15 2011


  • Cyclic GMP
  • Differentiation
  • Free radicals
  • Nitric oxide
  • Stem cells

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)


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