Abstract
To study the appropriateness of phlebotomy for digoxin therapeutic drug monitoring (TDM) in outpatients, we conducted a retrospective chart review, a computer search of all previous TDM testing, and a questionnaire of all outpatients (n = 86) who had serum digoxin determinations between April 10 and April 28, 1992 (585 tests). In patients who took digoxin at the same time daily (40 patients, 300 tests), 52% of tests were performed on inappropriate samples drawn within 6 h of the last dose. No patient who took digoxin after 1700 had inappropriate tests. Phlebotomy for serum digoxin determinations before distribution of digoxin is complete is a common problem in outpatients, leading to clinically uninterpretable test results. Post- distribution sampling can be assured by nighttime dosing, and this recommendation has been implemented at our hospital.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 45-49 |
| Number of pages | 5 |
| Journal | Clinical Chemistry |
| Volume | 42 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1996 |
Keywords
- blood sampling
- pharmacokinetics
ASJC Scopus subject areas
- Clinical Biochemistry
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