Nighttime dosing assures postdistribution sampling for therapeutic drug monitoring of digoxin

David W. Bernard; Richard L. Bowman; Freddy A. Grimm; Bryan A. Wolf; Michael B. Simson; Leslie M. Shaw

doi:10.1093/clinchem/42.1.45

Nighttime dosing assures postdistribution sampling for therapeutic drug monitoring of digoxin

David W. Bernard, Richard L. Bowman, Freddy A. Grimm, Bryan A. Wolf, Michael B. Simson, Leslie M. Shaw

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

To study the appropriateness of phlebotomy for digoxin therapeutic drug monitoring (TDM) in outpatients, we conducted a retrospective chart review, a computer search of all previous TDM testing, and a questionnaire of all outpatients (n = 86) who had serum digoxin determinations between April 10 and April 28, 1992 (585 tests). In patients who took digoxin at the same time daily (40 patients, 300 tests), 52% of tests were performed on inappropriate samples drawn within 6 h of the last dose. No patient who took digoxin after 1700 had inappropriate tests. Phlebotomy for serum digoxin determinations before distribution of digoxin is complete is a common problem in outpatients, leading to clinically uninterpretable test results. Post- distribution sampling can be assured by nighttime dosing, and this recommendation has been implemented at our hospital.

Original language	English (US)
Pages (from-to)	45-49
Number of pages	5
Journal	Clinical Chemistry
Volume	42
Issue number	1
DOIs	https://doi.org/10.1093/clinchem/42.1.45
State	Published - 1996

Keywords

blood sampling
pharmacokinetics

ASJC Scopus subject areas

Clinical Biochemistry

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10.1093/clinchem/42.1.45

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abstract = "To study the appropriateness of phlebotomy for digoxin therapeutic drug monitoring (TDM) in outpatients, we conducted a retrospective chart review, a computer search of all previous TDM testing, and a questionnaire of all outpatients (n = 86) who had serum digoxin determinations between April 10 and April 28, 1992 (585 tests). In patients who took digoxin at the same time daily (40 patients, 300 tests), 52% of tests were performed on inappropriate samples drawn within 6 h of the last dose. No patient who took digoxin after 1700 had inappropriate tests. Phlebotomy for serum digoxin determinations before distribution of digoxin is complete is a common problem in outpatients, leading to clinically uninterpretable test results. Post- distribution sampling can be assured by nighttime dosing, and this recommendation has been implemented at our hospital.",

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AU - Bernard, David W.

AU - Bowman, Richard L.

AU - Grimm, Freddy A.

AU - Wolf, Bryan A.

AU - Simson, Michael B.

AU - Shaw, Leslie M.

PY - 1996

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N2 - To study the appropriateness of phlebotomy for digoxin therapeutic drug monitoring (TDM) in outpatients, we conducted a retrospective chart review, a computer search of all previous TDM testing, and a questionnaire of all outpatients (n = 86) who had serum digoxin determinations between April 10 and April 28, 1992 (585 tests). In patients who took digoxin at the same time daily (40 patients, 300 tests), 52% of tests were performed on inappropriate samples drawn within 6 h of the last dose. No patient who took digoxin after 1700 had inappropriate tests. Phlebotomy for serum digoxin determinations before distribution of digoxin is complete is a common problem in outpatients, leading to clinically uninterpretable test results. Post- distribution sampling can be assured by nighttime dosing, and this recommendation has been implemented at our hospital.

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Nighttime dosing assures postdistribution sampling for therapeutic drug monitoring of digoxin

Abstract

Keywords

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