Nicotine patch therapy in smoking cessation reduces the extent of exercise-induced myocardial ischemia

John J. Mahmarian, Lemuel A. Moyé, George A. Nasser, Sherif Nagueh, Marilyn F. Bloom, Neal L. Benowitz, Mario S. Verani, William G. Byrd, Craig Pratt

Research output: Contribution to journalArticle

115 Scopus citations

Abstract

Objectives. We sought to determine the effects of nicotine patch therapy, when used to promote smoking cessation, on myocardial ischemia in patients with coronary artery disease. Background. Nicotine patches substantially increase quit rates among cigarette smokers, but their safety in patients with myocardial ischemia who are attempting to quit smoking is unknown. This is a prospective study using exercise thallium-201 single- photon emission computed tomography (SPECT) to assess serial changes in the total and ischemic myocardial perfusion defect size at baseline while patients were smoking and during treatment with 14- and 21-mg nicotine patches. Entry criteria required that patients 1) smoked ≤1 pack of cigarettes per day; 2) had known coronary artery disease; and 3) had myocardial ischemia (i.e., ≤5% reversible perfusion defect) on SPECT. All patients performed symptom-limited treadmill exercise, and the baseline SPECT study served as its own control. We interpreted and computer quantified the SPECT images with no knowledge of the testing sequence. Results. Thirty-six of the 40 enrolled patients had exercise SPECT at baseline and during treatment with at least 14-mg nicotine patches. These patients had an initial perfusion defect size of 17.5 ±10.6% while smoking an average of 31 ±11 cigarettes per day for 40 ± 12 years. A significant reduction in the total perfusion defect size (p < 0.001) was observed from baseline (17.5 ± 10.6%) to treatment with 14-mg (12.6 ±10.1%) and 21-mg (11.8 ± 9.9%) nicotine patches. This reduction occurred despite an increase in treadmill exercise duration (p < 0.05) higher serum nicotine levels (p < 0.001). There was a significant correlation between the reduction in defect size exhaled carbon monoxide levels (p < 0.001) because patients reduced their smoking by ~74% during the trial. Conclusions. Nicotine patches when used to promote smoking cessation significantly reduce the extent of exercise-induced myocardial ischemia as assessed by exercise thallium-201 SPECT.

Original languageEnglish (US)
Pages (from-to)125-130
Number of pages6
JournalJournal of the American College of Cardiology
Volume30
Issue number1
DOIs
StatePublished - Jul 1 1997

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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