Nicotine and angiogenesis: A new paradigm for tobacco-related diseases

John P. Cooke, Haim Bitterman

Research output: Contribution to journalReview articlepeer-review

104 Scopus citations


The pathophysiology of tobacco-related diseases is complex and multifactorial. Among the approximately 4,000 compounds in tobacco smoke are carcinogens such as nitrosamines, irritants such as a variety of phenolic compounds, volatiles such as carbon monoxide, and of course nicotine. Nicotine itself has quite complex actions, mediated in part by nicotinic cholinergic receptors that may have extraneuronal, as well as neuronal distribution. This review discusses the mechanisms by which nicotine contributes to tobacco-related disease, with a focus on the surprising new finding that nicotine is a potent angiogenic agent. Nicotine hijacks an endogenous nicotinic cholinergic pathway present in endothelial cells that is involved in physiological, as well as pathological angiogenesis.

Original languageEnglish (US)
Pages (from-to)33-40
Number of pages8
JournalAnnals of Medicine
Issue number1
StatePublished - 2004


  • Atherosclerosis
  • Coronary artery disease
  • Endothelium

ASJC Scopus subject areas

  • Medicine(all)


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