NF-κB signaling in inflammation and cancer

Tao Zhang, Chao Ma, Zhiqiang Zhang, Huiyuan Zhang, Hongbo Hu

Research output: Contribution to journalArticlepeer-review


Abstract Since nuclear factor of ?-light chain of enhancer-activated B cells (NF-?B) was discovered in 1986, extraordinary efforts have been made to understand the function and regulating mechanism of NF-?B for 35 years, which lead to significant progress. Meanwhile, the molecular mechanisms regulating NF-?B activation have also been illuminated, the cascades of signaling events leading to NF-?B activity and key components of the NF-?B pathway are also identified. It has been suggested NF-?B plays an important role in human diseases, especially inflammation-related diseases. These studies make the NF-?B an attractive target for disease treatment. This review aims to summarize the knowledge of the family members of NF-?B, as well as the basic mechanisms of NF-?B signaling pathway activation. We will also review the effects of dysregulated NF-?B on inflammation, tumorigenesis, and tumor microenvironment. The progression of the translational study and drug development targeting NF-?B for inflammatory diseases and cancer treatment and the potential obstacles will be discussed. Further investigations on the precise functions of NF-?B in the physiological and pathological settings and underlying mechanisms are in the urgent need to develop drugs targeting NF-?B for inflammatory diseases and cancer treatment, with minimal side effects.
Original languageEnglish (US)
Issue numbern/a
StatePublished - Dec 16 2021


  • cancer
  • immunity
  • inflammation
  • NF-κB
  • signal transduction


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