New understanding of the group A Streptococcus pathogenesis cycle

Anne H. Tart, Mark J. Walker, James M. Musser

Research output: Contribution to journalReview articlepeer-review

94 Scopus citations


Group A Streptococcus (GAS) has long been recognized as a human pathogen causing an exceptionally broad range of infections. Despite intense research, however, the molecular mechanisms of GAS disease remain unclear. Recently, many important discoveries have been made that shed light on GAS pathogenesis and open exciting avenues for future research. Advances in genome sequencing, microarray technology and proteomic analysis, in combination with the development of more suitable animal models, have markedly increased our knowledge of the mechanisms underlying GAS pathogenesis. The information gained from these studies will translate into improved diagnostics and new targets for therapeutic drugs and vaccines.

Original languageEnglish (US)
Pages (from-to)318-325
Number of pages8
JournalTrends in Microbiology
Issue number7
StatePublished - Jul 2007

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology


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