New polyfunctional magnesium reagents for organic synthesis

Mario Rottländer; Laure Boymond; Laurent Bérillon; Anne Leprêtre; Greta Varchi; Salvatore Avolio; Hamid Laaziri; Guy Quéguiner; Alfredo Ricci; Gérard Cahiez; Paul Knochel

doi:10.1002/(SICI)1521-3765(20000303)6:5<767::AID-CHEM767>3.0.CO;2-X

New polyfunctional magnesium reagents for organic synthesis

Mario Rottländer, Laure Boymond, Laurent Bérillon, Anne Leprêtre, Greta Varchi, Salvatore Avolio, Hamid Laaziri, Guy Quéguiner, Alfredo Ricci, Gérard Cahiez, Paul Knochel

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

The iodine-magnesium exchange reaction allows the preparation of polyfunctional aryl, heteroaryl, or alkenyl magnesium reagents at low temperature. These reagents display the typical reactivity of Grignard compounds and undergo various copper-catalyzed reactions such as allylation or 1,4-addition. Using this halogen -metal exchange reaction, it was possible to generate polyfunctional magnesium reagents on the solid phase.

Original language	English (US)
Pages (from-to)	767-770
Number of pages	4
Journal	Chemistry - A European Journal
Volume	6
Issue number	5
DOIs	https://doi.org/10.1002/(SICI)1521-3765(20000303)6:5<767::AID-CHEM767>3.0.CO;2-X
State	Published - Mar 3 2000

Keywords

Catalysis
Copper
Cyclizations
Hetero-cycles
Magnesium
Solid-phase synthesis

ASJC Scopus subject areas

Catalysis
General Chemistry
Organic Chemistry

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10.1002/(SICI)1521-3765(20000303)6:5<767::AID-CHEM767>3.0.CO;2-X

Cite this

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title = "New polyfunctional magnesium reagents for organic synthesis",

abstract = "The iodine-magnesium exchange reaction allows the preparation of polyfunctional aryl, heteroaryl, or alkenyl magnesium reagents at low temperature. These reagents display the typical reactivity of Grignard compounds and undergo various copper-catalyzed reactions such as allylation or 1,4-addition. Using this halogen -metal exchange reaction, it was possible to generate polyfunctional magnesium reagents on the solid phase.",

keywords = "Catalysis, Copper, Cyclizations, Hetero-cycles, Magnesium, Solid-phase synthesis",

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TY - JOUR

T1 - New polyfunctional magnesium reagents for organic synthesis

AU - Rottländer, Mario

AU - Boymond, Laure

AU - Bérillon, Laurent

AU - Leprêtre, Anne

AU - Varchi, Greta

AU - Avolio, Salvatore

AU - Laaziri, Hamid

AU - Quéguiner, Guy

AU - Ricci, Alfredo

AU - Cahiez, Gérard

AU - Knochel, Paul

PY - 2000/3/3

Y1 - 2000/3/3

N2 - The iodine-magnesium exchange reaction allows the preparation of polyfunctional aryl, heteroaryl, or alkenyl magnesium reagents at low temperature. These reagents display the typical reactivity of Grignard compounds and undergo various copper-catalyzed reactions such as allylation or 1,4-addition. Using this halogen -metal exchange reaction, it was possible to generate polyfunctional magnesium reagents on the solid phase.

AB - The iodine-magnesium exchange reaction allows the preparation of polyfunctional aryl, heteroaryl, or alkenyl magnesium reagents at low temperature. These reagents display the typical reactivity of Grignard compounds and undergo various copper-catalyzed reactions such as allylation or 1,4-addition. Using this halogen -metal exchange reaction, it was possible to generate polyfunctional magnesium reagents on the solid phase.

KW - Catalysis

KW - Copper

KW - Cyclizations

KW - Hetero-cycles

KW - Magnesium

KW - Solid-phase synthesis

UR - https://www.scopus.com/pages/publications/0037619382

UR - https://www.scopus.com/inward/citedby.url?scp=0037619382&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1521-3765(20000303)6:5<767::AID-CHEM767>3.0.CO;2-X

DO - 10.1002/(SICI)1521-3765(20000303)6:5<767::AID-CHEM767>3.0.CO;2-X

M3 - Article

AN - SCOPUS:0037619382

SN - 0947-6539

VL - 6

SP - 767

EP - 770

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 5

ER -

New polyfunctional magnesium reagents for organic synthesis

Abstract

Keywords

ASJC Scopus subject areas

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