New polyfunctional magnesium reagents for organic synthesis

Mario Rottländer, Laure Boymond, Laurent Bérillon, Anne Leprêtre, Greta Varchi, Salvatore Avolio, Hamid Laaziri, Guy Quéguiner, Alfredo Ricci, Gérard Cahiez, Paul Knochel

Research output: Contribution to journalArticlepeer-review

111 Scopus citations


The iodine-magnesium exchange reaction allows the preparation of polyfunctional aryl, heteroaryl, or alkenyl magnesium reagents at low temperature. These reagents display the typical reactivity of Grignard compounds and undergo various copper-catalyzed reactions such as allylation or 1,4-addition. Using this halogen -metal exchange reaction, it was possible to generate polyfunctional magnesium reagents on the solid phase.

Original languageEnglish (US)
Pages (from-to)767-770
Number of pages4
JournalChemistry - A European Journal
Issue number5
StatePublished - Mar 3 2000


  • Catalysis
  • Copper
  • Cyclizations
  • Hetero-cycles
  • Magnesium
  • Solid-phase synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Organic Chemistry


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