New polyfunctional magnesium reagents for organic synthesis

Mario Rottländer, Laure Boymond, Laurent Bérillon, Anne Leprêtre, Greta Varchi, Salvatore Avolio, Hamid Laaziri, Guy Quéguiner, Alfredo Ricci, Gérard Cahiez, Paul Knochel

    Research output: Contribution to journalArticlepeer-review

    111 Scopus citations

    Abstract

    The iodine-magnesium exchange reaction allows the preparation of polyfunctional aryl, heteroaryl, or alkenyl magnesium reagents at low temperature. These reagents display the typical reactivity of Grignard compounds and undergo various copper-catalyzed reactions such as allylation or 1,4-addition. Using this halogen -metal exchange reaction, it was possible to generate polyfunctional magnesium reagents on the solid phase.

    Original languageEnglish (US)
    Pages (from-to)767-770
    Number of pages4
    JournalChemistry - A European Journal
    Volume6
    Issue number5
    DOIs
    StatePublished - Mar 3 2000

    Keywords

    • Catalysis
    • Copper
    • Cyclizations
    • Hetero-cycles
    • Magnesium
    • Solid-phase synthesis

    ASJC Scopus subject areas

    • Catalysis
    • General Chemistry
    • Organic Chemistry

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