The iodine-magnesium exchange reaction allows the preparation of polyfunctional aryl, heteroaryl, or alkenyl magnesium reagents at low temperature. These reagents display the typical reactivity of Grignard compounds and undergo various copper-catalyzed reactions such as allylation or 1,4-addition. Using this halogen -metal exchange reaction, it was possible to generate polyfunctional magnesium reagents on the solid phase.
|Original language||English (US)|
|Number of pages||4|
|Journal||Chemistry - A European Journal|
|State||Published - Mar 3 2000|
- Solid-phase synthesis
ASJC Scopus subject areas
- Organic Chemistry