New Perspectives on Antimicrobial Agents: Long-Acting Lipoglycopeptides

Truc T. Tran, Sara Gomez Villegas, Samuel L. Aitken, Susan M. Butler-Wu, Alex Soriano, Brian J. Werth, Jose M. Munita

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The long-acting lipoglycopeptides (LGPs) dalbavancin and oritavancin are semisynthetic antimicrobials with broad and potent activity against Gram-positive bacterial pathogens. While they are approved by the Food and Drug Administration for acute bacterial skin and soft tissue infections, their pharmacological properties suggest a potential role of these agents for the treatment of deep-seated and severe infections, such as bloodstream and bone and joint infections. The use of these antimicrobials is particularly appealing when prolonged therapy, early discharge, and avoidance of long-term intravascular catheter access are desirable or when multidrug-resistant bacteria are suspected. This review describes the current evidence for the use of oritavancin and dalbavancin in the treatment of invasive infections, as well as the hurdles that are preventing their optimal use. Moreover, this review discusses the current knowledge gaps that need to be filled to understand the potential role of LGPs in highly needed clinical scenarios and the ongoing clinical studies that aim to address these voids in the upcoming years.

Original languageEnglish (US)
JournalAntimicrobial Agents and Chemotherapy
Volume66
Issue number6
DOIs
StatePublished - Jun 2022

Keywords

  • dalbavancin
  • lipoglycopeptide
  • oritavancin

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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