New-onset diabetes after transplantation: Results from a double-blind early corticosteroid withdrawal trial

J. D. Pirsch, A. K. Henning, M. R. First, W. Fitzsimmons, A. Osama Gaber, R. Reisfield, F. Shihab, E. S. Woodle

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

New-onset diabetes after transplantation (NODAT) is an important complication following kidney transplantation. Data from the 5-year early steroid withdrawal double-blind randomized trial were analyzed to determine if steroid avoidance reduced the NODAT risk. Incidence, timing and risk factors for NODAT were evaluated using eight definitions. By American Diabetes Association definition, 36.3% of patients on chronic corticosteroids (CCS) and 35.9% on early corticosteroid withdrawal (CSWD) were diagnosed with NODAT by 5 years. The definition combining fasting blood glucose ≥126-mg/dL on two occasions or treatment identified slightly more cases of NODAT: CCS (39.3%) and CSWD (39.4%). Through 5 years posttransplant, the proportion of NODAT patients requiring treatment were similar (CSWD 22.5% vs. CCS 21.5%); however, insulin therapy was lower with CSWD (3.7% vs. 11.6%; p-=-0.049). By multivariate analysis, only age, but not corticosteroid use, was a significant risk factor for NODAT for more than one definition. Numerical, but not statistically significant trends toward lower NODAT rates with CSWD were observed through 5 years for insulin use, HbA1c ≥6.0% and ≥6.5% on two occasions. This prospective, randomized trial of CSWD indicates that CSWD has a limited impact in reducing NODAT when compared to low-dose prednisone (5-mg/day from month 6 to 5 years). In this kidney transplantation study, the authors evaluate data from a 5-year early corticosteroid withdrawal double-blind randomized trial to determine if steroid avoidance reduces the risk of new-onset diabetes after transplantation.

Original languageEnglish (US)
Pages (from-to)1982-1990
Number of pages9
JournalAmerican Journal of Transplantation
Volume15
Issue number7
DOIs
StatePublished - Jul 1 2015

Keywords

  • Clinical research
  • diabetes: new onset
  • kidney transplantation
  • minimization
  • nephrology
  • posttransplant
  • practice
  • withdrawal

ASJC Scopus subject areas

  • Transplantation
  • Immunology and Allergy
  • Pharmacology (medical)

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