New hydroxyapatite nanophases with enhanced osteogenic and anti-bacterial activity

A. Ballardini, M. Montesi, S. Panseri, A. Vandini, P. G. Balboni, A. Tampieri, S. Sprio

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

This work describes the synthesis and characterization of new apatite phases co-doped with gallium, magnesium and carbonate, exhibiting osteogenic and antibacterial ability. The apatites are synthesized at low temperature to retain nanocrystallinity and controlled doping with the various bioactive foreign ions, as assessed by physico–chemical and crystallographic analyses, reporting the achievement of single phases with reduced crystal ordering. The analysis of single and multi-doped apatites reports to different mechanisms acting in the incorporation of gallium and magnesium ions in the apatite structure. The release of bioactive ions is correlated to the behavior of human mesenchymal stem cells and of different bacterial strands, selected among the most frequently affecting surgical procedures. Enhanced osteogenic and antibacterial ability is assessed in multi-doped apatites, thus suggesting potential future applications as new smart biomaterials integrating a significant boosting of bone regeneration with adequate protection against bacteria.

Original languageEnglish (US)
Pages (from-to)521-530
Number of pages10
JournalJournal of Biomedical Materials Research - Part A
Volume106
Issue number2
DOIs
StatePublished - Feb 1 2018

Keywords

  • antibacterial
  • biomimetic
  • gallium
  • osteogenic
  • substituted apatites

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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