Nya glukokortikoider görs mer selektiva: Dagens kunskaper kan eliminera allvarliga sidoeffekter

Translated title of the contribution: New glucocorticoids are more selective; serious side-effects can now be eliminated

Stefan Nilsson, Jan-Ake Gustafsson

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Glucocorticoids have been used as anti-inflammatory, anti-allergic and immunosuppressive agents since the beginning of the 1940s, and during recent years the mechanisms by which they exert their anti-inflammatory effects have begun to be better understood. Inhibition of inflammatory response is primarily mediated via the glucocorticoid receptor and the two transcription factors, AP-1 and NFκB, which are of crucial importance for the expression of pro-inflammatory cytokines and other genes involved in the inflammatory process. Unfortunately, long-term treatment with glucocorticoids is associated with a series of adverse effects such as hypertension, bone fragility, diabetes, dermatrophy and personality changes. However, owing to advances in biotechnology and recent clarification of the molecular mechanisms involved, it is now becoming possible to develop new glucocorticoids with a more selective antiinflammatory effect without serious side-effects.

Translated title of the contributionNew glucocorticoids are more selective; serious side-effects can now be eliminated
Original languageSwedish
Pages (from-to)2465-2471
Number of pages7
JournalLakartidningen
Issue number26-27
StatePublished - Jun 25 1997

ASJC Scopus subject areas

  • Medicine(all)

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