New agents for the treatment of fungal infections: Clinical efficacy and gaps in coverage

Elias K. Spaitakis, George Aperis, Eleftherios Mylonakis

Research output: Contribution to journalReview articlepeer-review

146 Scopus citations

Abstract

The incidence of fungal infections has increased globally, and the introduction of the newer triazoles and echinocandin antifungals is a more-than-welcome and long overdue development. In this report, we review the clinical trials evaluating the therapeutic efficacy of these new antifungal agents and examine possible gaps in coverage. Voriconazole has become the primary treatment for most forms of invasive aspergillosis in a number of centers, posaconazole offers a broad antifungal spectrum, and echinocandins are fungicidal against most Candida species. Moreover, the new agents are active against some fungi that are resistant to amphotericin B, may have a role in the management of fever and neutropenia, and provide exciting options for combination antifungal therapy. However, significant questions remain, including the management of breakthrough infections and treatment failures and the efficacy of the new antifungal agents against less common fungi.

Original languageEnglish (US)
Pages (from-to)1060-1068
Number of pages9
JournalClinical Infectious Diseases
Volume43
Issue number8
DOIs
StatePublished - Oct 15 2006

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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