Neurotoxicological consequence of long-term exposure to lanthanum

Liuxing Feng, Haiqing Xiao, Xiao He, Zijie Li, Fuliang Li, Nianqing Liu, Yuliang Zhao, Yuying Huang, Zhiyong Zhang, Zhifang Chai

Research output: Contribution to journalArticle

113 Scopus citations

Abstract

Lanthanides, because of their diversified physical and chemical effects, have been widely used in a number of fields. As a result, more and more lanthanides are entering into the environment and eventually accumulated in human body. Recently, a new medicine, lanthanum carbonate (Fosrenol), has been used to treat chronic renal failure (CRF), and the dosage is much higher than the daily intake of lanthanides. However, the effects of lanthanides on human body, especially on the central nervous system, are still unclear. The aim of this study was to determine whether long-term lanthanum exposure results in persistent alternations in nervous system function. Wistar rats were exposed to lanthanum chloride (LaCl3) through oral administration at 0, 0.1, 2 and 40 mg/kg concentration from 4 weeks through 6 months of age. Morris water maze test showed that lanthanum exposure at 40 mg/kg could significantly impair the behavioral performance. To fully investigate the neurotoxicological consequence of lanthanum exposure, brain elemental distributions and neurochemicals were also investigated. The distributions of brain elements such as Ca, Fe and Zn were significantly altered after lanthanum exposure. Moreover, 40 mg/kg LaCl3 significantly inhibited the activity of Ca2+-ATPase; the function of the central cholinergic system was also noticeably disturbed and the contents of some monoamines neurotransmitters were significantly decreased. These findings indicate that chronic exposure to lanthanum could possibly impair the learning ability and this deficit may be possibly attributed to the disturbance of the homeostasis of trace elements, enzymes and neurotransmitter systems in brain. Therefore, the application of lanthanide, especially in pharmacology, should be cautious.

Original languageEnglish (US)
Pages (from-to)112-120
Number of pages9
JournalToxicology Letters
Volume165
Issue number2
DOIs
StatePublished - Aug 20 2006

Keywords

  • Brain element
  • Lanthanum
  • Neurotransmitter
  • Toxicology

ASJC Scopus subject areas

  • Toxicology

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