TY - JOUR
T1 - Neurosurgery and quantum dots
T2 - Part I - State of the art
AU - Khalessi, Alexander A.
AU - Liu, Charles Y.
AU - Apuzzo, Michael L.J.
PY - 2009/6
Y1 - 2009/6
N2 - THIS ARTICLE REPRESENTS the first of a 2-part exploration of quantum dots (Qdots) and their application to neurological surgery. Spanning from materials science to immunology, this initial review traces the marriage of imaging physics to biochemical specificity. Qdot science now stands poised to dramatically advance the diagnosis and therapy of neurosurgical conditions. Qdot research efforts currently involve several disciplines; this comprehensive review therefore considers multiple fields of inquiry. This first installment discusses 1) Qdot physical properties, 2) established biological and in vivo properties, 3) magnetic resonance imaging applications, and (4) existing cardiovascular and oncologic research. Finally, this review establishes the existing bounds of Qdot possibilities. The second concept article details future endovascular diagnostic and therapeutic methods derived from these seminal advances.
AB - THIS ARTICLE REPRESENTS the first of a 2-part exploration of quantum dots (Qdots) and their application to neurological surgery. Spanning from materials science to immunology, this initial review traces the marriage of imaging physics to biochemical specificity. Qdot science now stands poised to dramatically advance the diagnosis and therapy of neurosurgical conditions. Qdot research efforts currently involve several disciplines; this comprehensive review therefore considers multiple fields of inquiry. This first installment discusses 1) Qdot physical properties, 2) established biological and in vivo properties, 3) magnetic resonance imaging applications, and (4) existing cardiovascular and oncologic research. Finally, this review establishes the existing bounds of Qdot possibilities. The second concept article details future endovascular diagnostic and therapeutic methods derived from these seminal advances.
KW - Endovascular neurosurgery
KW - Magnetic resonance imaging
KW - Nanomedicine
KW - Nanotechnology
KW - Polymer drug delivery
KW - Quantum dots
UR - http://www.scopus.com/inward/record.url?scp=68049085690&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68049085690&partnerID=8YFLogxK
U2 - 10.1227/01.NEU.0000347889.62762.3F
DO - 10.1227/01.NEU.0000347889.62762.3F
M3 - Review article
C2 - 19487880
AN - SCOPUS:68049085690
SN - 0148-396X
VL - 64
SP - 1015
EP - 1027
JO - Neurosurgery
JF - Neurosurgery
IS - 6
ER -