Neuropsychological outcome following intensity-modulated radiation therapy for pediatric medulloblastoma

Neelam Jain, Kevin R. Krull, Pim Brouwers, Murali Chintagumpala, Shiao Y. Woo

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Background. Combined cisplatin chemotherapy and cranial irradiation for treatment of medulloblastoma in children can cause significant ototoxicity and impair cognitive function and quality of life. We have previously demonstrated the conformal technique of intensity-modulated radiation therapy (IMRT) to reduce ototoxicity, however, it has been suggested that IMRT may increase risk of cognitive deficits compared to conventional radiation therapy (CRT). This study compared the impact of the two treatments on measures of neurocognitive functioning. Procedure. Twenty-five pediatric patients with medulloblastoma were treated either with CRT or IMRT. In addition they received neurocognitive assessments to evaluate long-term functional outcome. Statistical analyses between the two groups were conducted to compare levels and profiles of performance on tests not confounded with hearing loss. Results. When compared to CRT, children treated with IMRT did not perform more poorly on any of the measures. Both groups' mean performance was significantly lower than published norms on several of the measures employed. Conclusion. The benefit of reduced ototoxicity with IMRT does not appear to be at the cost of a decline in nonverbal intellectual abilities, visual-spatial skills, processing speed, or fine motor dexterity when compared to CRT in children with medulloblastoma.

Original languageEnglish (US)
Pages (from-to)275-279
Number of pages5
JournalPediatric Blood and Cancer
Volume51
Issue number2
DOIs
StatePublished - Aug 2008

Keywords

  • CNS tumors
  • Late effects of treatment
  • Neuropsychology
  • Radiation oncology

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Medicine(all)

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