Neurons of nucleus of the solitary tract synchronize the EEG and elevate cerebral blood flow via a novel medullary area

Eugene V. Golanov, Donald J. Reis

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

In anesthetized spinalized rat, electrical stimulation of the nucleus tractus solitarius (NTS) synchronizes the EEG by increasing the power of 4-6-Hz waves (>100%; P<0.01), and elevates cerebral blood flow (rCBF) by 18±5% (P<0.05). The coordinated response appears within seconds, is global, reversible, graded, evoked from the commissural sub-nucleus, and replicated by L-glutamate. The responses are markedly reduced by bilateral lesions or muscimol microinjections restricted to a region of ventral medullary reticular formation, the medullary cerebral vasodilator area (MCVA), a region from which stimulation elicits identical responses and mediates the comparable responses to hypoxic/ischemic excitation of sympathoexcitatory neurons of rostral ventrolateral medulla (RVLM). We conclude that: (a) excitation of intrinsic neurons of commissural NTS synchronizes the EEG and coordinately elevates rCBF; (b) the responses are mediated by excitation of neurons in MCVA; (c) the MCVA may be a common final pathway mediating cerebrovascular and EEG responses from multiple areas of CNS; and (d) the NTS-MCVA pathway may be a part of the anatomical substrate for behaviors, including slow-wave sleep and seizure suppression evoked by stimulation of visceral afferents terminating in NTS.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalBrain Research
Volume892
Issue number1
DOIs
StatePublished - Feb 16 2001

Keywords

  • Cerebral blood flow
  • EEG
  • Nucleus tractus solitarius
  • Rostral ventrolateral medulla

ASJC Scopus subject areas

  • Neuroscience(all)

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