La neuroimagen en la enfermedad de Alzheimer: Perspectiva actual

Translated title of the contribution: Neuroimaging in Alzheimer's disease: An overview

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Introduction. Clinically, computerized tomography scanning and magnetic resonance imaging (MRI) are the neuroimaging techniques most frequently used in the work up of progressive cognitive impairment, in order to rule out tumors or other treatable etiologies. However, as we move closer to having more effective treatments for Alzheimer's disease (AD), we experience a greater need to use markers of early brain injury. Among them is neuroimaging. Narrative. In this review we give some examples of the role of MRI and of functional MRI (fMRI) as markers of early brain changes. Regional metabolism, studied with positron emission tomography (PET) can also be used advantageously to depict early cortical changes in mild cognitive impairment (MCI) and even presymptomatic AD. SPECT, less expensive than PET, has a lower sensitivity, but has been extensively studied and using quantification methods can help even in MCI. Newer PET markers allow for the evaluation of activated microglia in vivo as well as for the study of amyloid deposition in the brain and the activity of enzymes such as acetyl-cholinesterase. Conclusion: Future refinements in the neuroimaging techniques seem likely to help in the early diagnosis, evaluation of potential treatments and clarification of pathogenetic mechanisms in AD.

Translated title of the contributionNeuroimaging in Alzheimer's disease: An overview
Original languageSpanish
Pages (from-to)1156-1165
Number of pages10
JournalRevista de Neurologia
Volume38
Issue number12
DOIs
StatePublished - Jul 16 2004

Keywords

  • Alzheimer's disease
  • Dementia
  • Functional neuroimaging
  • Magnetic resonance imaging
  • PET
  • SPECT

ASJC Scopus subject areas

  • Clinical Neurology

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