Neurogenic plasticity of mesenchymal stem cell, an alluring cellular replacement for traumatic brain injury

Soumya Pati, Sangu Muthuraju, Raisah Ab Hadi, Tee Jong Huat, Shailja Singh, Mirjana Maletic-Savatic, Jafri Malin Abdullah, Hasnan Jaafar

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Traumatic brain injury (TBI) imposes horrendous neurophysiological alterations leading to most devastating forms of neuro-disability. Which includes impaired cognition, distorted locomotors activity and psychosomatic disability in both youths and adults. Emerging evidence from recent studies has identified mesenchymal stem cells (MSCs) as one of the promising category of stem cells having excellent neuroregenerative capability in TBI victims. Some of the clinical and animal studies reported that MSCs transplantation could cure neuronal damage as well as improve cognitive and locomotors behaviors in TBI. However, mechanism behind their broad spectrum neuroregenerative potential in TBI has not been reviewed yet. Therefore, in the present article, we present a comprehensive data on the important attributes of MSCs, such as neuro- transdifferentiation, neuroprotection, axonal repair and plasticity, maintenance of blood-brain integrity, reduction of reactive oxygen species (ROS) and immunomodulation. We have reviewed in detail the crucial neurogenic capabilities of MSCs in vivo and provided consolidated knowledge regarding their cellular remodeling in TBI for future therapeutic implications.

Original languageEnglish (US)
Pages (from-to)149-157
Number of pages9
JournalCurrent Stem Cell Research and Therapy
Volume11
Issue number2
DOIs
StatePublished - Jan 1 2016

Keywords

  • Immunomodulation and therapeutic
  • Mesenchymal stem cells
  • Neuro-transdifferentiation
  • Traumatic brain injury

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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