Neurofibromatosis 1 mRNA expression in blood vessels

Joy A. Ahlgren-Beckendorf; William W. Maggio; Feng Chen; Thomas A. Kent

doi:10.1006/bbrc.1993.2580

Neurofibromatosis 1 mRNA expression in blood vessels

Joy A. Ahlgren-Beckendorf, William W. Maggio, Feng Chen, Thomas A. Kent

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Vascular hypertrophic lesions occur in neurofibromatosis type 1 (NF1). The role of the gene which causes NF1 in the growth and development of blood vessels is not known. mRNA expression of the NF1 gene was studied in blood vessels in the transition between intact and culture and in quiescent and proliferative conditions. The expression and alternative splicing pattern of the catalytic domain of NF1 consistently changed in proliferating cells, supporting a role for this gene in the regulation of growth of vascular smooth muscle and the vascular pathology in NF1.

Original language	English (US)
Pages (from-to)	1019-1024
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	197
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1993.2580
State	Published - 1993

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1006/bbrc.1993.2580

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abstract = "Vascular hypertrophic lesions occur in neurofibromatosis type 1 (NF1). The role of the gene which causes NF1 in the growth and development of blood vessels is not known. mRNA expression of the NF1 gene was studied in blood vessels in the transition between intact and culture and in quiescent and proliferative conditions. The expression and alternative splicing pattern of the catalytic domain of NF1 consistently changed in proliferating cells, supporting a role for this gene in the regulation of growth of vascular smooth muscle and the vascular pathology in NF1.",

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year = "1993",

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AU - Ahlgren-Beckendorf, Joy A.

AU - Maggio, William W.

AU - Chen, Feng

AU - Kent, Thomas A.

PY - 1993

Y1 - 1993

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AB - Vascular hypertrophic lesions occur in neurofibromatosis type 1 (NF1). The role of the gene which causes NF1 in the growth and development of blood vessels is not known. mRNA expression of the NF1 gene was studied in blood vessels in the transition between intact and culture and in quiescent and proliferative conditions. The expression and alternative splicing pattern of the catalytic domain of NF1 consistently changed in proliferating cells, supporting a role for this gene in the regulation of growth of vascular smooth muscle and the vascular pathology in NF1.

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Neurofibromatosis 1 mRNA expression in blood vessels

Abstract

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