Neurofibromatosis 1 mRNA expression in blood vessels

Joy A. Ahlgren-Beckendorf, William W. Maggio, Feng Chen, Thomas A. Kent

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Vascular hypertrophic lesions occur in neurofibromatosis type 1 (NF1). The role of the gene which causes NF1 in the growth and development of blood vessels is not known. mRNA expression of the NF1 gene was studied in blood vessels in the transition between intact and culture and in quiescent and proliferative conditions. The expression and alternative splicing pattern of the catalytic domain of NF1 consistently changed in proliferating cells, supporting a role for this gene in the regulation of growth of vascular smooth muscle and the vascular pathology in NF1.

Original languageEnglish (US)
Pages (from-to)1019-1024
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume197
Issue number2
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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