Neuroendocrine dysfunction in cluster headache

M. Leone, G. Patruno, Angelo Vescovi, G. Bussone

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Current views on cluster headache pathogenesis indicate a primary central nervous system dysfunction, in particular a hypothalamic involvement. To confirm the hypothalamic involvement in cluster headache we evaluated the hypothalamic-pituitary axis responsiveness with the thyrotrophin releasing hormone (TRH) test. A dose of 200 μg of TRH was administered i.v. to nine healthy controls, 32 patients with cluster headache during cluster period and 16 in remission period. Delta maximum thyrotrophin (TSH) was significantly lower in patients with cluster headache during cluster period (p < 0.05 versus healthy controls and cluster headache patients in remission). No difference was observed between healthy controls and cluster headache patients in remission. A monoaminergic dysfunction at the hypothalamic level is hypothesized.

Original languageEnglish (US)
Pages (from-to)235-239
Number of pages5
JournalCephalalgia
Volume10
Issue number5
DOIs
StatePublished - Jan 1 1990

Keywords

  • Cluster period
  • TRH test
  • hypothalamic-pituitary axis
  • monoaminergic dysfunction
  • reduced TSH response

ASJC Scopus subject areas

  • Clinical Neurology

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