Neural Correlates of Message Tailoring and Self-Relatedness in Smoking Cessation Programming

Hannah Faye Chua, Israel Liberzon, Robert C. Welsh, Victor J. Strecher

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


Background: Smoking leads to illnesses including addiction, cancer, and cardiovascular and respiratory diseases. Different intervention programs have become available. In the past decade, providing tailored smoking cessation messages has been shown to be more effective in inducing smoking cessation than one-size-fits-all interventions. However, little is known about the brain responses of smokers when they receive tailored smoking cessation messages. Methods: A neuroimaging study using blocked and event-related designs examined neural activity in 24 smokers exposed to high-tailored and low-tailored smoking cessation messages. Results: In both blocked and event-related conditions, rostral medial prefrontal cortex and precuneus/posterior cingulate were engaged more during the processing of high-tailored smoking cessation messages than low-tailored smoking cessation messages. Conclusions: The activation patterns of smokers to tailored cessation messages show involvement of brain areas commonly implicated in self-related processing. Results seem to add support to the suggested role of self-relevance in tailored cessation programs, where previous studies have shown a potential mediating role of self-relevance on smoking abstinence. The findings are relevant to understanding the cognitive mechanisms underlying tailored message processing and might point to new directions for testing response to health communications programming.

Original languageEnglish (US)
Pages (from-to)165-168
Number of pages4
JournalBiological Psychiatry
Issue number2
StatePublished - Jan 15 2009


  • Addiction
  • fMRI
  • nicotine
  • self
  • smoking cessation
  • tailoring

ASJC Scopus subject areas

  • Biological Psychiatry


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