Nested case-control study of the emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae

Masayuki Nigo; Catalina Salinas Cevallos; Krystina Woods; Vicente Maco Flores; Gweneth Francis; David C. Perlman; Manuel Revuelta; Donna Mildvan; Mary Waldron; Tessa Gomez; Sanjana Koshy; Tomasz Jodlowski; William Riley; Jörg J. Ruhe

doi:10.1128/AAC.00827-13

Nested case-control study of the emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae

Masayuki Nigo, Catalina Salinas Cevallos, Krystina Woods, Vicente Maco Flores, Gweneth Francis, David C. Perlman, Manuel Revuelta, Donna Mildvan, Mary Waldron, Tessa Gomez, Sanjana Koshy, Tomasz Jodlowski, William Riley, Jörg J. Ruhe

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21 Scopus citations

Abstract

We performed a nested case-control study (ratio of 1:4) on the emergence of tigecycline-resistant multidrug-resistant Klebsiella pneumoniae (TR-MDRKP) isolates among patients who initially presented with a tigecycline-susceptible MDRKP isolate. Out of 260 patients, 24 (9%) had a subsequent clinical culture positive for a TR-MDRKP isolate within the 90-day follow-up period. On logistic regression analyses, receipt of tigecycline (adjusted odds ratio [OR], 5.06; 95% confidence interval [CI], 1.80 to 14.23; P= 0.002) was the only independent predictor of subsequent isolation of a TR strain.

Original language	English (US)
Pages (from-to)	5743-5746
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	57
Issue number	11
DOIs	https://doi.org/10.1128/AAC.00827-13
State	Published - Nov 2013

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Nigo, M., Cevallos, C. S., Woods, K., Flores, V. M., Francis, G., Perlman, D. C., Revuelta, M., Mildvan, D., Waldron, M., Gomez, T., Koshy, S., Jodlowski, T., Riley, W., & Ruhe, J. J. (2013). Nested case-control study of the emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy, 57(11), 5743-5746. https://doi.org/10.1128/AAC.00827-13

Nigo, M, Cevallos, CS, Woods, K, Flores, VM, Francis, G, Perlman, DC, Revuelta, M, Mildvan, D, Waldron, M, Gomez, T, Koshy, S, Jodlowski, T, Riley, W & Ruhe, JJ 2013, 'Nested case-control study of the emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae', Antimicrobial Agents and Chemotherapy, vol. 57, no. 11, pp. 5743-5746. https://doi.org/10.1128/AAC.00827-13

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abstract = "We performed a nested case-control study (ratio of 1:4) on the emergence of tigecycline-resistant multidrug-resistant Klebsiella pneumoniae (TR-MDRKP) isolates among patients who initially presented with a tigecycline-susceptible MDRKP isolate. Out of 260 patients, 24 (9%) had a subsequent clinical culture positive for a TR-MDRKP isolate within the 90-day follow-up period. On logistic regression analyses, receipt of tigecycline (adjusted odds ratio [OR], 5.06; 95% confidence interval [CI], 1.80 to 14.23; P= 0.002) was the only independent predictor of subsequent isolation of a TR strain.",

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AU - Flores, Vicente Maco

AU - Francis, Gweneth

AU - Perlman, David C.

AU - Revuelta, Manuel

AU - Mildvan, Donna

AU - Waldron, Mary

AU - Gomez, Tessa

AU - Koshy, Sanjana

AU - Jodlowski, Tomasz

AU - Riley, William

AU - Ruhe, Jörg J.

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Nested case-control study of the emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae

Abstract

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