Neonatal androgenic programming of hepatic steroid metabolism in rats

Jan Åke Gustafsson; Magnus Ingelman-Sundberg; Åke Stenbeŕg

doi:10.1016/0022-4731(75)90046-1

Neonatal androgenic programming of hepatic steroid metabolism in rats

Jan Åke Gustafsson, Magnus Ingelman-Sundberg, Åke Stenbeŕg

Houston Methodist

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Hepatic metabolism of steroid hormones in the rat is sexually differentiated at birth by irreversible programming ("imprinting") by testicular androgens. The regulation of sex-dependent enzyme activities in the rat has been shown to be under hypothalamico-hypophyseal control. Probably this control is mainly exerted via a pituitary "feminizing factor" the secretion of which is suppressed in the male rat by a hypothalamic inhibiting factor. The production of this inhibiting factor is "turned on" by neonatal androgenic imprinting.

Original language	English (US)
Pages (from-to)	643-649
Number of pages	7
Journal	Journal of Steroid Biochemistry
Volume	6
Issue number	5
DOIs	https://doi.org/10.1016/0022-4731(75)90046-1
State	Published - May 1975

ASJC Scopus subject areas

Biochemistry
Endocrinology

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10.1016/0022-4731(75)90046-1

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title = "Neonatal androgenic programming of hepatic steroid metabolism in rats",

abstract = "Hepatic metabolism of steroid hormones in the rat is sexually differentiated at birth by irreversible programming ({"}imprinting{"}) by testicular androgens. The regulation of sex-dependent enzyme activities in the rat has been shown to be under hypothalamico-hypophyseal control. Probably this control is mainly exerted via a pituitary {"}feminizing factor{"} the secretion of which is suppressed in the male rat by a hypothalamic inhibiting factor. The production of this inhibiting factor is {"}turned on{"} by neonatal androgenic imprinting.",

author = "Gustafsson, \{Jan {\AA}ke\} and Magnus Ingelman-Sundberg and {\AA}ke Stenbe{\'r}g",

note = "Funding Information: Acknowlrd\textasciitilde{}rmrntsThis work was supported by grants from the Swedish Medical Research Council (13X-2819) and from the World Health Organization. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "1975",

month = may,

doi = "10.1016/0022-4731(75)90046-1",

language = "English (US)",

volume = "6",

pages = "643--649",

journal = "Journal of Steroid Biochemistry",

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T1 - Neonatal androgenic programming of hepatic steroid metabolism in rats

AU - Gustafsson, Jan Åke

AU - Ingelman-Sundberg, Magnus

AU - Stenbeŕg, Åke

N1 - Funding Information: Acknowlrd~rmrntsThis work was supported by grants from the Swedish Medical Research Council (13X-2819) and from the World Health Organization. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 1975/5

Y1 - 1975/5

N2 - Hepatic metabolism of steroid hormones in the rat is sexually differentiated at birth by irreversible programming ("imprinting") by testicular androgens. The regulation of sex-dependent enzyme activities in the rat has been shown to be under hypothalamico-hypophyseal control. Probably this control is mainly exerted via a pituitary "feminizing factor" the secretion of which is suppressed in the male rat by a hypothalamic inhibiting factor. The production of this inhibiting factor is "turned on" by neonatal androgenic imprinting.

AB - Hepatic metabolism of steroid hormones in the rat is sexually differentiated at birth by irreversible programming ("imprinting") by testicular androgens. The regulation of sex-dependent enzyme activities in the rat has been shown to be under hypothalamico-hypophyseal control. Probably this control is mainly exerted via a pituitary "feminizing factor" the secretion of which is suppressed in the male rat by a hypothalamic inhibiting factor. The production of this inhibiting factor is "turned on" by neonatal androgenic imprinting.

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AN - SCOPUS:0016808177

SN - 0022-4731

VL - 6

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EP - 649

JO - Journal of Steroid Biochemistry

JF - Journal of Steroid Biochemistry

IS - 5

ER -

Neonatal androgenic programming of hepatic steroid metabolism in rats

Abstract

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