Neonatal androgenic programming of hepatic steroid metabolism in rats

Jan Åke Gustafsson, Magnus Ingelman-Sundberg, Åke Stenbeŕg

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Hepatic metabolism of steroid hormones in the rat is sexually differentiated at birth by irreversible programming ("imprinting") by testicular androgens. The regulation of sex-dependent enzyme activities in the rat has been shown to be under hypothalamico-hypophyseal control. Probably this control is mainly exerted via a pituitary "feminizing factor" the secretion of which is suppressed in the male rat by a hypothalamic inhibiting factor. The production of this inhibiting factor is "turned on" by neonatal androgenic imprinting.

Original languageEnglish (US)
Pages (from-to)643-649
Number of pages7
JournalJournal of Steroid Biochemistry
Volume6
Issue number5
DOIs
StatePublished - May 1975

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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