Neocortical neural sprouting, synaptogenesis, and behavioral recovery after neocortical infarction in rats

R. Paul Stroemer; Thomas A. Kent; Claire E. Hulsebosch

doi:10.1161/01.STR.26.11.2135

Neocortical neural sprouting, synaptogenesis, and behavioral recovery after neocortical infarction in rats

R. Paul Stroemer, Thomas A. Kent, Claire E. Hulsebosch

Research output: Contribution to journal › Article › peer-review

464 Scopus citations

Abstract

Background and PurposeNeuroanatomical plasticity is well described in lesions of the hippocampus but remains a subject of some controversy in the neocortex. The purpose of the present study was to measure the neocortical distribution and density of expression of proteins known to be involved in neurite growth or synaptogenesis and to correlate the neocortical expression with behavioral recovery after a focal neocortical infarction. Focal neocortical infarction creates a circumscribed lesion in the neocortex that provides a denervation stimulus for neurite growth and synaptogenesis.

Original language	English (US)
Pages (from-to)	2135-2144
Number of pages	10
Journal	Stroke
Volume	26
Issue number	11
DOIs	https://doi.org/10.1161/01.STR.26.11.2135
State	Published - Nov 1995

ASJC Scopus subject areas

Clinical Neurology
Cardiology and Cardiovascular Medicine
Advanced and Specialized Nursing

Access to Document

10.1161/01.STR.26.11.2135

Cite this

@article{aae07b32d5de48b683d5213030834742,

title = "Neocortical neural sprouting, synaptogenesis, and behavioral recovery after neocortical infarction in rats",

abstract = "Background and PurposeNeuroanatomical plasticity is well described in lesions of the hippocampus but remains a subject of some controversy in the neocortex. The purpose of the present study was to measure the neocortical distribution and density of expression of proteins known to be involved in neurite growth or synaptogenesis and to correlate the neocortical expression with behavioral recovery after a focal neocortical infarction. Focal neocortical infarction creates a circumscribed lesion in the neocortex that provides a denervation stimulus for neurite growth and synaptogenesis.",

author = "Stroemer, {R. Paul} and Kent, {Thomas A.} and Hulsebosch, {Claire E.}",

year = "1995",

month = nov,

doi = "10.1161/01.STR.26.11.2135",

language = "English (US)",

volume = "26",

pages = "2135--2144",

journal = "Stroke",

issn = "0039-2499",

publisher = "American Heart Association",

number = "11",

}

TY - JOUR

T1 - Neocortical neural sprouting, synaptogenesis, and behavioral recovery after neocortical infarction in rats

AU - Stroemer, R. Paul

AU - Kent, Thomas A.

AU - Hulsebosch, Claire E.

PY - 1995/11

Y1 - 1995/11

N2 - Background and PurposeNeuroanatomical plasticity is well described in lesions of the hippocampus but remains a subject of some controversy in the neocortex. The purpose of the present study was to measure the neocortical distribution and density of expression of proteins known to be involved in neurite growth or synaptogenesis and to correlate the neocortical expression with behavioral recovery after a focal neocortical infarction. Focal neocortical infarction creates a circumscribed lesion in the neocortex that provides a denervation stimulus for neurite growth and synaptogenesis.

AB - Background and PurposeNeuroanatomical plasticity is well described in lesions of the hippocampus but remains a subject of some controversy in the neocortex. The purpose of the present study was to measure the neocortical distribution and density of expression of proteins known to be involved in neurite growth or synaptogenesis and to correlate the neocortical expression with behavioral recovery after a focal neocortical infarction. Focal neocortical infarction creates a circumscribed lesion in the neocortex that provides a denervation stimulus for neurite growth and synaptogenesis.

UR - http://www.scopus.com/inward/record.url?scp=0028808693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028808693&partnerID=8YFLogxK

U2 - 10.1161/01.STR.26.11.2135

DO - 10.1161/01.STR.26.11.2135

M3 - Article

C2 - 7482662

AN - SCOPUS:0028808693

VL - 26

SP - 2135

EP - 2144

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 11

ER -

Neocortical neural sprouting, synaptogenesis, and behavioral recovery after neocortical infarction in rats

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this