Neocortical neural sprouting, synaptogenesis, and behavioral recovery after neocortical infarction in rats

R. Paul Stroemer, Thomas A. Kent, Claire E. Hulsebosch

Research output: Contribution to journalArticle

438 Scopus citations

Abstract

Background and PurposeNeuroanatomical plasticity is well described in lesions of the hippocampus but remains a subject of some controversy in the neocortex. The purpose of the present study was to measure the neocortical distribution and density of expression of proteins known to be involved in neurite growth or synaptogenesis and to correlate the neocortical expression with behavioral recovery after a focal neocortical infarction. Focal neocortical infarction creates a circumscribed lesion in the neocortex that provides a denervation stimulus for neurite growth and synaptogenesis.

Original languageEnglish (US)
Pages (from-to)2135-2144
Number of pages10
JournalStroke
Volume26
Issue number11
DOIs
StatePublished - Nov 1995

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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