Nelfinavir plasma concentrations in patients experiencing early failure with nelfinavir-containing triple combinations

Daniel Gonzàlez De Requena; Marina Núñez; Carmen De Mendoza; Inmaculada Jiménez-Nàcher; Vincent Soriano

doi:10.1097/00002030-200302140-00020

Nelfinavir plasma concentrations in patients experiencing early failure with nelfinavir-containing triple combinations

Daniel Gonzàlez De Requena, Marina Núñez, Carmen De Mendoza, Inmaculada Jiménez-Nàcher, Vincent Soriano

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Virological failure to protease inhibitor (PI)-based antiretroviral regimens is often not explained by the selection of PI resistance mutations. The role of low PI plasma levels in treatment failure was assessed in 30 patients failing nelfinavir-containing triple combinations. Approximately a third of the patients showed sub-therapeutic nelfinavir plasma levels. More than two-thirds of them had no drug resistance mutations, suggesting that insufficient nelfinavir levels contributed to treatment failure.

Original language	English (US)
Pages (from-to)	442-444
Number of pages	3
Journal	AIDS
Volume	17
Issue number	3
DOIs	https://doi.org/10.1097/00002030-200302140-00020
State	Published - Feb 14 2003

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1097/00002030-200302140-00020

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abstract = "Virological failure to protease inhibitor (PI)-based antiretroviral regimens is often not explained by the selection of PI resistance mutations. The role of low PI plasma levels in treatment failure was assessed in 30 patients failing nelfinavir-containing triple combinations. Approximately a third of the patients showed sub-therapeutic nelfinavir plasma levels. More than two-thirds of them had no drug resistance mutations, suggesting that insufficient nelfinavir levels contributed to treatment failure.",

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AU - Gonzàlez De Requena, Daniel

AU - Núñez, Marina

AU - De Mendoza, Carmen

AU - Jiménez-Nàcher, Inmaculada

AU - Soriano, Vincent

PY - 2003/2/14

Y1 - 2003/2/14

N2 - Virological failure to protease inhibitor (PI)-based antiretroviral regimens is often not explained by the selection of PI resistance mutations. The role of low PI plasma levels in treatment failure was assessed in 30 patients failing nelfinavir-containing triple combinations. Approximately a third of the patients showed sub-therapeutic nelfinavir plasma levels. More than two-thirds of them had no drug resistance mutations, suggesting that insufficient nelfinavir levels contributed to treatment failure.

AB - Virological failure to protease inhibitor (PI)-based antiretroviral regimens is often not explained by the selection of PI resistance mutations. The role of low PI plasma levels in treatment failure was assessed in 30 patients failing nelfinavir-containing triple combinations. Approximately a third of the patients showed sub-therapeutic nelfinavir plasma levels. More than two-thirds of them had no drug resistance mutations, suggesting that insufficient nelfinavir levels contributed to treatment failure.

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ER -

Nelfinavir plasma concentrations in patients experiencing early failure with nelfinavir-containing triple combinations

Abstract

ASJC Scopus subject areas

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