TY - JOUR
T1 - Nelfinavir plasma concentrations in patients experiencing early failure with nelfinavir-containing triple combinations
AU - Gonzàlez De Requena, Daniel
AU - Núñez, Marina
AU - De Mendoza, Carmen
AU - Jiménez-Nàcher, Inmaculada
AU - Soriano, Vincent
PY - 2003/2/14
Y1 - 2003/2/14
N2 - Virological failure to protease inhibitor (PI)-based antiretroviral regimens is often not explained by the selection of PI resistance mutations. The role of low PI plasma levels in treatment failure was assessed in 30 patients failing nelfinavir-containing triple combinations. Approximately a third of the patients showed sub-therapeutic nelfinavir plasma levels. More than two-thirds of them had no drug resistance mutations, suggesting that insufficient nelfinavir levels contributed to treatment failure.
AB - Virological failure to protease inhibitor (PI)-based antiretroviral regimens is often not explained by the selection of PI resistance mutations. The role of low PI plasma levels in treatment failure was assessed in 30 patients failing nelfinavir-containing triple combinations. Approximately a third of the patients showed sub-therapeutic nelfinavir plasma levels. More than two-thirds of them had no drug resistance mutations, suggesting that insufficient nelfinavir levels contributed to treatment failure.
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U2 - 10.1097/00002030-200302140-00020
DO - 10.1097/00002030-200302140-00020
M3 - Article
C2 - 12556700
AN - SCOPUS:0037436236
SN - 0269-9370
VL - 17
SP - 442
EP - 444
JO - AIDS
JF - AIDS
IS - 3
ER -