TY - JOUR
T1 - Neck circumference might predict gestational diabetes mellitus in Han Chinese women
T2 - A nested case–control study
AU - He, Fang
AU - He, Hua
AU - Liu, Wenqi
AU - Lin, Junyu
AU - Chen, Bingjun
AU - Lin, Yucong
AU - Zhao, Yitao
AU - Tao, Wen
AU - Xia, Xuefeng
N1 - Funding Information:
We greatly acknowledge the biochemistry laboratory of Third Hospital Affiliated to Guangzhou Medical University for their technical help. We also thank Athena Ren and Guoyue Yuan for their invaluable comments during discussions. This study was supported by the National Natural Science Foundation of China (no. 81270868 to X. X.).
Publisher Copyright:
© 2016 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Aims/Introduction: A large neck circumference might be an indicator of metabolic syndrome and its components, and for certain patients is more practical as an index than waist circumference. The demarcation value for neck circumference that suggests metabolic syndrome appears to vary by ethnic group. Gestational diabetes mellitus is considered a component of metabolic syndrome in pregnant women. We investigated whether neck circumference in Han Chinese women is associated with gestational diabetes mellitus in early pregnancy, and determined a predictive demarcation value. Materials and Methods: A nested case–control study was carried out with 255 women aged 18–35 years. Gestational diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association through a 2-h, 75-g oral glucose tolerance test. Results: Of the total population, 41 (16%) women developed gestational diabetes mellitus by 24–28 weeks of gestation. Neck circumference at gestational week 16 positively correlated with pre-pregnancy waist circumference, bodyweight and body mass index, and maternal age (P = 0.029) and hemoglobin A1c at gestational week 24 (P ≤ 0.001). By binary logistic regression, neck circumference was an independent predictor of gestational diabetes mellitus (odds ratio 1.840, 95% confidence interval 1.040–3.254; P = 0.036). According to the receiver operating characteristic curve, for predicting gestational diabetes mellitus the optimal demarcation for neck circumference at gestational week 16 was 35.15 cm. Conclusions: Neck circumference is a viable tool to screen for gestational diabetes mellitus. In this population of pregnant Han Chinese women, a neck circumference of ≥35.15 cm was a predictor of gestational diabetes mellitus.
AB - Aims/Introduction: A large neck circumference might be an indicator of metabolic syndrome and its components, and for certain patients is more practical as an index than waist circumference. The demarcation value for neck circumference that suggests metabolic syndrome appears to vary by ethnic group. Gestational diabetes mellitus is considered a component of metabolic syndrome in pregnant women. We investigated whether neck circumference in Han Chinese women is associated with gestational diabetes mellitus in early pregnancy, and determined a predictive demarcation value. Materials and Methods: A nested case–control study was carried out with 255 women aged 18–35 years. Gestational diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association through a 2-h, 75-g oral glucose tolerance test. Results: Of the total population, 41 (16%) women developed gestational diabetes mellitus by 24–28 weeks of gestation. Neck circumference at gestational week 16 positively correlated with pre-pregnancy waist circumference, bodyweight and body mass index, and maternal age (P = 0.029) and hemoglobin A1c at gestational week 24 (P ≤ 0.001). By binary logistic regression, neck circumference was an independent predictor of gestational diabetes mellitus (odds ratio 1.840, 95% confidence interval 1.040–3.254; P = 0.036). According to the receiver operating characteristic curve, for predicting gestational diabetes mellitus the optimal demarcation for neck circumference at gestational week 16 was 35.15 cm. Conclusions: Neck circumference is a viable tool to screen for gestational diabetes mellitus. In this population of pregnant Han Chinese women, a neck circumference of ≥35.15 cm was a predictor of gestational diabetes mellitus.
KW - Gestational diabetes mellitus
KW - Metabolic syndrome
KW - Neck circumference
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U2 - 10.1111/jdi.12574
DO - 10.1111/jdi.12574
M3 - Article
C2 - 27589681
AN - SCOPUS:84991494473
SN - 2040-1116
VL - 8
SP - 168
EP - 173
JO - Journal of Diabetes Investigation
JF - Journal of Diabetes Investigation
IS - 2
ER -