Nd3+-Sensitized Upconversion Metal–Organic Frameworks for Mitochondria-Targeted Amplified Photodynamic Therapy

Chang Liu, Bei Liu, Jian Zhao, Zhenghan Di, Daquan Chen, Zhanjun Gu, Lele Li, Yuliang Zhao

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Herein, we report the design and synthesis of a mitochondria-specific, 808 nm NIR light-activated photodynamic therapy (PDT) system based on the combination of metal–organic frameworks (MOFs) and upconversion photochemistry with an organelle-targeting strategy. The system was synthesized through the growth of a porphyrinic MOF on Nd3+-sensitized upconversion nanoparticles to achieve Janus nanostructures with further asymmetric functionalization of the surface of the MOF domain. The PDT nanoplatform allows for photosensitizing with 808 nm NIR light, which could effectively avoid the laser-irradiation-induced overheating effect. Furthermore, mitochondria-targeting could amplify PDT efficacy through the depolarization of the mitochondrial membrane and the initiation of intrinsic apoptotic pathway. This work sheds light on the hybrid engineering of MOFs to combat their current limitations for PDT.

Original languageEnglish (US)
Pages (from-to)2634-2638
Number of pages5
JournalAngewandte Chemie - International Edition
Volume59
Issue number7
DOIs
StatePublished - Feb 10 2020

Keywords

  • metal–organic frameworks
  • mitochondria
  • photodynamic therapy
  • theranostics
  • upconversion nanotechnology

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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