Nd3+ sensitized dumbbell-like upconversion nanoparticles for photodynamic therapy application

Bing Xu; Xiao Zhang; Wenjuan Huang; Yijun Yang; Ying Ma; Zhanjun Gu; Tianyou Zhai; Yuliang Zhao

doi:10.1039/c6tb00542j

Nd³⁺ sensitized dumbbell-like upconversion nanoparticles for photodynamic therapy application

Bing Xu, Xiao Zhang, Wenjuan Huang, Yijun Yang, Ying Ma, Zhanjun Gu, Tianyou Zhai, Yuliang Zhao

Houston Methodist

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Better tissue penetration and lower overheating problems mean 808 nm near-infrared laser excited upconversion nanoparticles (UCNPs) have potential in bioapplications. Dumbbell-like structured NaYF₄:Yb/Er@NaNdF₄:Yb nanoparticles are fabricated in this work and applied in photodynamic therapy (PDT). The epitaxial growth along the c axis attributed to the large structure mismatch of NaNdF₄versus NaYF₄ has been demonstrated to play a key role in the growth of the dumbbell structure. Due to better space separation in this structure, energy back-transfer from Er³⁺ to Nd³⁺ is prohibited partially, and the optimized Nd³⁺ doping concentration is up to 90% for a high UC emission intensity. PDT effects of these dumbbell-like structured UCNPs upon 808 nm laser irradiation were examined and compared with isotropic NaYF₄:Yb/Er@NaYF₄:Nd_0.2 core-shell and NaYF₄:Yb/Er@NaYF₄:Nd_0.2@NaYF₄ core-shell-shell UCNPs. The results show that the dumbbell-like UCNPs are most effective in generating singlet oxygen (¹O₂) and killing cancer cells in PDT though their UC emission intensity is lower than that of the core-shell-shell UCNPs. This research presents a simple yet valid strategy to balance the UCL efficiency and FRET efficiency, which may lead to better PDT therapeutic effect for cancer therapy.

Original language	English (US)
Pages (from-to)	2776-2784
Number of pages	9
Journal	Journal of Materials Chemistry B
Volume	4
Issue number	16
DOIs	https://doi.org/10.1039/c6tb00542j
State	Published - Apr 28 2016

ASJC Scopus subject areas

General Chemistry
Biomedical Engineering
General Materials Science

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@article{cf1594bfce0c4122851b05cf485dad0f,

title = "Nd3+ sensitized dumbbell-like upconversion nanoparticles for photodynamic therapy application",

abstract = "Better tissue penetration and lower overheating problems mean 808 nm near-infrared laser excited upconversion nanoparticles (UCNPs) have potential in bioapplications. Dumbbell-like structured NaYF4:Yb/Er@NaNdF4:Yb nanoparticles are fabricated in this work and applied in photodynamic therapy (PDT). The epitaxial growth along the c axis attributed to the large structure mismatch of NaNdF4versus NaYF4 has been demonstrated to play a key role in the growth of the dumbbell structure. Due to better space separation in this structure, energy back-transfer from Er3+ to Nd3+ is prohibited partially, and the optimized Nd3+ doping concentration is up to 90% for a high UC emission intensity. PDT effects of these dumbbell-like structured UCNPs upon 808 nm laser irradiation were examined and compared with isotropic NaYF4:Yb/Er@NaYF4:Nd0.2 core-shell and NaYF4:Yb/Er@NaYF4:Nd0.2@NaYF4 core-shell-shell UCNPs. The results show that the dumbbell-like UCNPs are most effective in generating singlet oxygen (1O2) and killing cancer cells in PDT though their UC emission intensity is lower than that of the core-shell-shell UCNPs. This research presents a simple yet valid strategy to balance the UCL efficiency and FRET efficiency, which may lead to better PDT therapeutic effect for cancer therapy.",

author = "Bing Xu and Xiao Zhang and Wenjuan Huang and Yijun Yang and Ying Ma and Zhanjun Gu and Tianyou Zhai and Yuliang Zhao",

note = "Funding Information: We acknowledge support from the National Natural Science Foundation of China (21273249, 31571015), National Basic Research Program of China (973 program, No. 2012CB932500 and 2015CB932600), the program for the HUST Interdisciplinary Innovation Team (2015ZDTD038) and the Fundamental Research Funds for the Central University. The authors also thank the State Key Laboratory of Materials Processing and Die & Mould Technology of HUST and the Analytical and Testing Centre of HUST for the characterizations. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",

year = "2016",

month = apr,

day = "28",

doi = "10.1039/c6tb00542j",

language = "English (US)",

volume = "4",

pages = "2776--2784",

journal = "Journal of Materials Chemistry B",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Nd3+ sensitized dumbbell-like upconversion nanoparticles for photodynamic therapy application

AU - Xu, Bing

AU - Zhang, Xiao

AU - Huang, Wenjuan

AU - Yang, Yijun

AU - Ma, Ying

AU - Gu, Zhanjun

AU - Zhai, Tianyou

AU - Zhao, Yuliang

N1 - Funding Information: We acknowledge support from the National Natural Science Foundation of China (21273249, 31571015), National Basic Research Program of China (973 program, No. 2012CB932500 and 2015CB932600), the program for the HUST Interdisciplinary Innovation Team (2015ZDTD038) and the Fundamental Research Funds for the Central University. The authors also thank the State Key Laboratory of Materials Processing and Die & Mould Technology of HUST and the Analytical and Testing Centre of HUST for the characterizations. Publisher Copyright: © The Royal Society of Chemistry 2016.

PY - 2016/4/28

Y1 - 2016/4/28

N2 - Better tissue penetration and lower overheating problems mean 808 nm near-infrared laser excited upconversion nanoparticles (UCNPs) have potential in bioapplications. Dumbbell-like structured NaYF4:Yb/Er@NaNdF4:Yb nanoparticles are fabricated in this work and applied in photodynamic therapy (PDT). The epitaxial growth along the c axis attributed to the large structure mismatch of NaNdF4versus NaYF4 has been demonstrated to play a key role in the growth of the dumbbell structure. Due to better space separation in this structure, energy back-transfer from Er3+ to Nd3+ is prohibited partially, and the optimized Nd3+ doping concentration is up to 90% for a high UC emission intensity. PDT effects of these dumbbell-like structured UCNPs upon 808 nm laser irradiation were examined and compared with isotropic NaYF4:Yb/Er@NaYF4:Nd0.2 core-shell and NaYF4:Yb/Er@NaYF4:Nd0.2@NaYF4 core-shell-shell UCNPs. The results show that the dumbbell-like UCNPs are most effective in generating singlet oxygen (1O2) and killing cancer cells in PDT though their UC emission intensity is lower than that of the core-shell-shell UCNPs. This research presents a simple yet valid strategy to balance the UCL efficiency and FRET efficiency, which may lead to better PDT therapeutic effect for cancer therapy.

AB - Better tissue penetration and lower overheating problems mean 808 nm near-infrared laser excited upconversion nanoparticles (UCNPs) have potential in bioapplications. Dumbbell-like structured NaYF4:Yb/Er@NaNdF4:Yb nanoparticles are fabricated in this work and applied in photodynamic therapy (PDT). The epitaxial growth along the c axis attributed to the large structure mismatch of NaNdF4versus NaYF4 has been demonstrated to play a key role in the growth of the dumbbell structure. Due to better space separation in this structure, energy back-transfer from Er3+ to Nd3+ is prohibited partially, and the optimized Nd3+ doping concentration is up to 90% for a high UC emission intensity. PDT effects of these dumbbell-like structured UCNPs upon 808 nm laser irradiation were examined and compared with isotropic NaYF4:Yb/Er@NaYF4:Nd0.2 core-shell and NaYF4:Yb/Er@NaYF4:Nd0.2@NaYF4 core-shell-shell UCNPs. The results show that the dumbbell-like UCNPs are most effective in generating singlet oxygen (1O2) and killing cancer cells in PDT though their UC emission intensity is lower than that of the core-shell-shell UCNPs. This research presents a simple yet valid strategy to balance the UCL efficiency and FRET efficiency, which may lead to better PDT therapeutic effect for cancer therapy.

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JO - Journal of Materials Chemistry B

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ER -

Nd³⁺ sensitized dumbbell-like upconversion nanoparticles for photodynamic therapy application

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