ncRNA therapy with miRNA-22-3p suppresses the growth of triple-negative breast cancer

Aysegul Gorur, Recep Bayraktar, Cristina Ivan, Hamada Ahmed Mokhlis, Emine Bayraktar, Nermin Kahraman, Didem Karakas, Selda Karamil, Nashwa N. Kabil, Pinar Kanlikilicer, Burcu Aslan, Lulufer Tamer, Zhihui Wang, Vittorio Cristini, Gabriel Lopez-Berestein, George Calin, Bulent Ozpolat

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Our study demonstrates that microRNA-22-3p (miR-22-3p) acts as a tumor suppressor in which its expression is markedly reduced in TNBC tumors. Restoration of its expression by miR-22-3p nanotherapy suppress tumor growth and progression by directly inhibiting of eEF2K-PI3K/AKT and Src signaling. miR-22-3p-based RNA therapy may be novel treatment for TNBC.

Original languageEnglish (US)
Pages (from-to)930-943
Number of pages14
JournalMolecular Therapy - Nucleic Acids
Volume23
DOIs
StatePublished - Mar 5 2021

Keywords

  • Akt
  • EF2K
  • PI3K
  • Src
  • breast cancer
  • eEF2K
  • gene regulation
  • gene silencing
  • liposomes
  • miR-22
  • nanoparticles
  • therapy
  • triple-negative breast cancer
  • tumor suppressor

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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