Natural killer cell lymphoma/leukemia with homozygous loss of p27/kip1

Fadel A. Sharif; Yesim Yilmaz; Arthur Zieske; Mazin B. Qumsiyeh

doi:10.1080/10428190500080397

Natural killer cell lymphoma/leukemia with homozygous loss of p27/kip1

Fadel A. Sharif, Yesim Yilmaz, Arthur Zieske, Mazin B. Qumsiyeh

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2 Scopus citations

Abstract

We describe a case of natural killer (NK) cell lymphoma/leukemia with only an interstitial deletion in the short arm of chromosome 12 as the primary event. Fluorescence in situ hybridization revealed that the ETV6 locus (12p13) and subtelomeric sequences are not deleted in the process. The p27/kip1 locus (12p12-13), a candidate tumor suppressor gene, was deleted on the abnormal chromosome. Sequence analysis detected an adenine nucleotide deletion in the third codon of exon 1 leading to frameshift and premature termination at codon 41 of the retained copy of p27/kip1. To the best of our knowledge, this is the first report in literature on a NK cell lymphoma/leukemia with complete loss of p27/kip1.

Original language	English (US)
Pages (from-to)	919-923
Number of pages	5
Journal	Leukemia and Lymphoma
Volume	46
Issue number	6
DOIs	https://doi.org/10.1080/10428190500080397
State	Published - Jun 2005

Keywords

Natural killer cell leukemia
p27/kip

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1080/10428190500080397

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title = "Natural killer cell lymphoma/leukemia with homozygous loss of p27/kip1",

abstract = "We describe a case of natural killer (NK) cell lymphoma/leukemia with only an interstitial deletion in the short arm of chromosome 12 as the primary event. Fluorescence in situ hybridization revealed that the ETV6 locus (12p13) and subtelomeric sequences are not deleted in the process. The p27/kip1 locus (12p12-13), a candidate tumor suppressor gene, was deleted on the abnormal chromosome. Sequence analysis detected an adenine nucleotide deletion in the third codon of exon 1 leading to frameshift and premature termination at codon 41 of the retained copy of p27/kip1. To the best of our knowledge, this is the first report in literature on a NK cell lymphoma/leukemia with complete loss of p27/kip1.",

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AU - Sharif, Fadel A.

AU - Yilmaz, Yesim

AU - Zieske, Arthur

AU - Qumsiyeh, Mazin B.

PY - 2005/6

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N2 - We describe a case of natural killer (NK) cell lymphoma/leukemia with only an interstitial deletion in the short arm of chromosome 12 as the primary event. Fluorescence in situ hybridization revealed that the ETV6 locus (12p13) and subtelomeric sequences are not deleted in the process. The p27/kip1 locus (12p12-13), a candidate tumor suppressor gene, was deleted on the abnormal chromosome. Sequence analysis detected an adenine nucleotide deletion in the third codon of exon 1 leading to frameshift and premature termination at codon 41 of the retained copy of p27/kip1. To the best of our knowledge, this is the first report in literature on a NK cell lymphoma/leukemia with complete loss of p27/kip1.

AB - We describe a case of natural killer (NK) cell lymphoma/leukemia with only an interstitial deletion in the short arm of chromosome 12 as the primary event. Fluorescence in situ hybridization revealed that the ETV6 locus (12p13) and subtelomeric sequences are not deleted in the process. The p27/kip1 locus (12p12-13), a candidate tumor suppressor gene, was deleted on the abnormal chromosome. Sequence analysis detected an adenine nucleotide deletion in the third codon of exon 1 leading to frameshift and premature termination at codon 41 of the retained copy of p27/kip1. To the best of our knowledge, this is the first report in literature on a NK cell lymphoma/leukemia with complete loss of p27/kip1.

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Natural killer cell lymphoma/leukemia with homozygous loss of p27/kip1

Abstract

Keywords

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