Natural killer cell lymphoma/leukemia with homozygous loss of p27/kip1

Fadel A. Sharif, Yesim Yilmaz, Arthur Zieske, Mazin B. Qumsiyeh

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We describe a case of natural killer (NK) cell lymphoma/leukemia with only an interstitial deletion in the short arm of chromosome 12 as the primary event. Fluorescence in situ hybridization revealed that the ETV6 locus (12p13) and subtelomeric sequences are not deleted in the process. The p27/kip1 locus (12p12-13), a candidate tumor suppressor gene, was deleted on the abnormal chromosome. Sequence analysis detected an adenine nucleotide deletion in the third codon of exon 1 leading to frameshift and premature termination at codon 41 of the retained copy of p27/kip1. To the best of our knowledge, this is the first report in literature on a NK cell lymphoma/leukemia with complete loss of p27/kip1.

Original languageEnglish (US)
Pages (from-to)919-923
Number of pages5
JournalLeukemia and Lymphoma
Volume46
Issue number6
DOIs
StatePublished - Jun 2005

Keywords

  • Natural killer cell leukemia
  • p27/kip

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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