Natural killer cell lymphoma/leukemia with homozygous loss of p27/kip1

Fadel A. Sharif; Yesim Yilmaz; Arthur Zieske; Mazin B. Qumsiyeh

doi:10.1080/10428190500080397

Natural killer cell lymphoma/leukemia with homozygous loss of p27/kip1

Fadel A. Sharif, Yesim Yilmaz, Arthur Zieske, Mazin B. Qumsiyeh

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We describe a case of natural killer (NK) cell lymphoma/leukemia with only an interstitial deletion in the short arm of chromosome 12 as the primary event. Fluorescence in situ hybridization revealed that the ETV6 locus (12p13) and subtelomeric sequences are not deleted in the process. The p27/kip1 locus (12p12-13), a candidate tumor suppressor gene, was deleted on the abnormal chromosome. Sequence analysis detected an adenine nucleotide deletion in the third codon of exon 1 leading to frameshift and premature termination at codon 41 of the retained copy of p27/kip1. To the best of our knowledge, this is the first report in literature on a NK cell lymphoma/leukemia with complete loss of p27/kip1.

Original language	English (US)
Pages (from-to)	919-923
Number of pages	5
Journal	Leukemia and Lymphoma
Volume	46
Issue number	6
DOIs	https://doi.org/10.1080/10428190500080397
State	Published - Jun 2005

Keywords

Natural killer cell leukemia
p27/kip

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

Access to Document

10.1080/10428190500080397

Cite this

@article{0a46bd05f8cc46b6b14f5c144879adce,

title = "Natural killer cell lymphoma/leukemia with homozygous loss of p27/kip1",

abstract = "We describe a case of natural killer (NK) cell lymphoma/leukemia with only an interstitial deletion in the short arm of chromosome 12 as the primary event. Fluorescence in situ hybridization revealed that the ETV6 locus (12p13) and subtelomeric sequences are not deleted in the process. The p27/kip1 locus (12p12-13), a candidate tumor suppressor gene, was deleted on the abnormal chromosome. Sequence analysis detected an adenine nucleotide deletion in the third codon of exon 1 leading to frameshift and premature termination at codon 41 of the retained copy of p27/kip1. To the best of our knowledge, this is the first report in literature on a NK cell lymphoma/leukemia with complete loss of p27/kip1.",

keywords = "Natural killer cell leukemia, p27/kip",

author = "Sharif, {Fadel A.} and Yesim Yilmaz and Arthur Zieske and Qumsiyeh, {Mazin B.}",

year = "2005",

month = jun,

doi = "10.1080/10428190500080397",

language = "English (US)",

volume = "46",

pages = "919--923",

journal = "Leukemia and Lymphoma",

issn = "1042-8194",

publisher = "Informa Healthcare",

number = "6",

}

TY - JOUR

T1 - Natural killer cell lymphoma/leukemia with homozygous loss of p27/kip1

AU - Sharif, Fadel A.

AU - Yilmaz, Yesim

AU - Zieske, Arthur

AU - Qumsiyeh, Mazin B.

PY - 2005/6

Y1 - 2005/6

N2 - We describe a case of natural killer (NK) cell lymphoma/leukemia with only an interstitial deletion in the short arm of chromosome 12 as the primary event. Fluorescence in situ hybridization revealed that the ETV6 locus (12p13) and subtelomeric sequences are not deleted in the process. The p27/kip1 locus (12p12-13), a candidate tumor suppressor gene, was deleted on the abnormal chromosome. Sequence analysis detected an adenine nucleotide deletion in the third codon of exon 1 leading to frameshift and premature termination at codon 41 of the retained copy of p27/kip1. To the best of our knowledge, this is the first report in literature on a NK cell lymphoma/leukemia with complete loss of p27/kip1.

AB - We describe a case of natural killer (NK) cell lymphoma/leukemia with only an interstitial deletion in the short arm of chromosome 12 as the primary event. Fluorescence in situ hybridization revealed that the ETV6 locus (12p13) and subtelomeric sequences are not deleted in the process. The p27/kip1 locus (12p12-13), a candidate tumor suppressor gene, was deleted on the abnormal chromosome. Sequence analysis detected an adenine nucleotide deletion in the third codon of exon 1 leading to frameshift and premature termination at codon 41 of the retained copy of p27/kip1. To the best of our knowledge, this is the first report in literature on a NK cell lymphoma/leukemia with complete loss of p27/kip1.

KW - Natural killer cell leukemia

KW - p27/kip

UR - http://www.scopus.com/inward/record.url?scp=21844452669&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21844452669&partnerID=8YFLogxK

U2 - 10.1080/10428190500080397

DO - 10.1080/10428190500080397

M3 - Article

C2 - 16019539

AN - SCOPUS:21844452669

SN - 1042-8194

VL - 46

SP - 919

EP - 923

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

IS - 6

ER -

Natural killer cell lymphoma/leukemia with homozygous loss of p27/kip1

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this