TY - JOUR
T1 - Natural genetic engineering
T2 - A programmed chromosome/DNA elimination
AU - Kloc, Malgorzata
AU - Kubiak, Jacek Z.
AU - Ghobrial, Rafik M.
N1 - Funding Information:
M. Kloc dedicates this paper to the memory of Prof. Kraczkiewicz who studied chromosome elimination in the gall midge (Cecidomyiidae) insects at Warsaw University in Poland from 1935 until his passing in 1971. Prof. Kraczkiewicz was Dr. Kloc's first mentor of cell biology at the University of Warsaw, Poland. The images of oocytes he showed during his lectures sparked Dr. Kloc's life-long fascination with oocytes and germ cell determination. She will always remember Professor Kraczkiewicz with a great fondness and gratitude for focusing her love of biology on these enchanting subjects. We also acknowledge that some of the drawings used to make figures were from the Servier Medical ART: SMART, smart.servier.com.
Publisher Copyright:
© 2022
PY - 2022/6
Y1 - 2022/6
N2 - Typically, all cells of a given organism have the same set of chromosomes. However, there are exceptions to this rule, and in many organisms, the somatic cells and germ cells, various types of somatic cells or organs, or females and males, have different genomes. One of the sources of such differences is chromosome/DNA elimination/chromatin diminution that is a naturally programmed phenomenon. We describe chromosome/DNA elimination in various organisms and present the current hypotheses on its origin, mechanisms, significance, and consequences.
AB - Typically, all cells of a given organism have the same set of chromosomes. However, there are exceptions to this rule, and in many organisms, the somatic cells and germ cells, various types of somatic cells or organs, or females and males, have different genomes. One of the sources of such differences is chromosome/DNA elimination/chromatin diminution that is a naturally programmed phenomenon. We describe chromosome/DNA elimination in various organisms and present the current hypotheses on its origin, mechanisms, significance, and consequences.
KW - B chromosomes
KW - Chromosome drive
KW - Chromosome elimination
KW - Diminution
KW - Gene silencing
KW - Programmed DNA elimination
KW - Repetitive sequences
KW - Super-mendelian inheritance
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U2 - 10.1016/j.ydbio.2022.03.008
DO - 10.1016/j.ydbio.2022.03.008
M3 - Review article
C2 - 35321809
AN - SCOPUS:85126866541
VL - 486
SP - 15
EP - 25
JO - Developmental Biology
JF - Developmental Biology
SN - 0012-1606
ER -