Native valve endocarditis caused by Corynebacterium striatum with heterogeneous high-level daptomycin resistance: Collateral damage from daptomycin therapy?

Truc T. Tran; Siraya Jaijakul; Cole T. Lewis; Lorena Diaz; Diana Panesso; Heidi B. Kaplan; Barbara E. Murray; Audrey Wanger; Cesar A. Arias

doi:10.1128/AAC.00046-12

Native valve endocarditis caused by Corynebacterium striatum with heterogeneous high-level daptomycin resistance: Collateral damage from daptomycin therapy?

Truc T. Tran, Siraya Jaijakul, Cole T. Lewis, Lorena Diaz, Diana Panesso, Heidi B. Kaplan, Barbara E. Murray, Audrey Wanger, Cesar A. Arias

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51 Scopus citations

Abstract

We describe a patient who developed Corynebacterium striatum native valve endocarditis after receiving two 6-week courses of daptomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis. The organism exhibited in vitro heteroresistance to daptomycin, with two subpopulations showing daptomycin susceptibility (MIC of <0.094 ≤g/ml) and high-level resistance to daptomycin (MIC of>256 ≥g/ml). The selection of daptomycin-resistant Gram-positive skin flora with the potential of causing invasive disease may be a concern during prolonged courses of daptomycin.

Original language	English (US)
Pages (from-to)	3461-3464
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	56
Issue number	6
DOIs	https://doi.org/10.1128/AAC.00046-12
State	Published - Jun 2012

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Tran, T. T., Jaijakul, S., Lewis, C. T., Diaz, L., Panesso, D., Kaplan, H. B., Murray, B. E., Wanger, A., & Arias, C. A. (2012). Native valve endocarditis caused by Corynebacterium striatum with heterogeneous high-level daptomycin resistance: Collateral damage from daptomycin therapy? Antimicrobial Agents and Chemotherapy, 56(6), 3461-3464. https://doi.org/10.1128/AAC.00046-12

Tran, TT, Jaijakul, S, Lewis, CT, Diaz, L, Panesso, D, Kaplan, HB, Murray, BE, Wanger, A & Arias, CA 2012, 'Native valve endocarditis caused by Corynebacterium striatum with heterogeneous high-level daptomycin resistance: Collateral damage from daptomycin therapy?', Antimicrobial Agents and Chemotherapy, vol. 56, no. 6, pp. 3461-3464. https://doi.org/10.1128/AAC.00046-12

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abstract = "We describe a patient who developed Corynebacterium striatum native valve endocarditis after receiving two 6-week courses of daptomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis. The organism exhibited in vitro heteroresistance to daptomycin, with two subpopulations showing daptomycin susceptibility (MIC of <0.094 ≤g/ml) and high-level resistance to daptomycin (MIC of>256 ≥g/ml). The selection of daptomycin-resistant Gram-positive skin flora with the potential of causing invasive disease may be a concern during prolonged courses of daptomycin.",

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AU - Lewis, Cole T.

AU - Diaz, Lorena

AU - Panesso, Diana

AU - Kaplan, Heidi B.

AU - Murray, Barbara E.

AU - Wanger, Audrey

AU - Arias, Cesar A.

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Native valve endocarditis caused by Corynebacterium striatum with heterogeneous high-level daptomycin resistance: Collateral damage from daptomycin therapy?

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