Native valve endocarditis caused by Corynebacterium striatum with heterogeneous high-level daptomycin resistance: Collateral damage from daptomycin therapy?

Truc T. Tran, Siraya Jaijakul, Cole T. Lewis, Lorena Diaz, Diana Panesso, Heidi B. Kaplan, Barbara E. Murray, Audrey Wanger, Cesar A. Arias

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

We describe a patient who developed Corynebacterium striatum native valve endocarditis after receiving two 6-week courses of daptomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis. The organism exhibited in vitro heteroresistance to daptomycin, with two subpopulations showing daptomycin susceptibility (MIC of <0.094 ≤g/ml) and high-level resistance to daptomycin (MIC of>256 ≥g/ml). The selection of daptomycin-resistant Gram-positive skin flora with the potential of causing invasive disease may be a concern during prolonged courses of daptomycin.

Original languageEnglish (US)
Pages (from-to)3461-3464
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume56
Issue number6
DOIs
StatePublished - Jun 2012

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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