Native and Reconstituted Plasma Lipoproteins in Nanomedicine: Physicochemical Determinants of Nanoparticle Structure, Stability, and Metabolism

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Although many acute and chronic diseases are managed via pharmacological means, challenges remain regarding appropriate drug targeting and maintenance of therapeutic levels within target tissues. Advances in nanotechnology will overcome these challenges through the development of lipidic particles, including liposomes, lipoproteins, and reconstituted high-density lipoproteins (rHDL) that are potential carriers of water-soluble, hydrophobic, and amphiphilic molecules. Herein we summarize the properties of human plasma lipoproteins and rHDL, identify the physicochemical determinants of lipid transfer between phospholipid surfaces, and discuss strategies for increasing the plasma half-life of lipoprotein- and liposome-associated molecules.

Original languageEnglish (US)
Pages (from-to)146-150
Number of pages5
JournalMethodist DeBakey cardiovascular journal
Volume12
Issue number3
DOIs
StatePublished - Sep 2016

Keywords

  • apolipoproteins
  • lipid metabolism
  • lipoprotein structure
  • liposomes
  • membrane dynamics
  • reconstituted HDL

ASJC Scopus subject areas

  • Medicine(all)

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