National Trends in Incidence and Outcomes of Patients With Heart Failure Requiring Respiratory Support

P. Elliott Miller, Shanti Patel, Aparna Saha, Avirup Guha, Sumeet Pawar, Priti Poojary, Parita Ratnani, Lili Chan, Stephan L. Kamholz, Carlos L. Alviar, Sean van Diepen, Khurram Nasir, Tariq Ahmad, Girish N. Nadkarni, Nihar R. Desai

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Despite increasing medical complexity in patients with heart failure (HF), there are limited data on incidence and outcomes for patients with HF needing respiratory support. This study sought to examine contemporary trends of respiratory support strategies among patients with HF. Using the National Inpatient Sample, we identified adults aged greater than 18 years hospitalized with a primary diagnosis of HF. We assessed for trends in the use of invasive mechanical ventilation (IMV) and noninvasive ventilation (NIV), length of stay, hospital costs, and in-hospital mortality. From 2002 to 2014, we identified 9,508,768 HF hospitalizations, which included 202,340 (2.13%) and 257,549 (2.71%) patients that required IMV and NIV, respectively. Over the study period, the proportion of HF patients requiring IMV significantly decreased (3.25% in 2002 to 1.56% in 2014) whereas the use of NIV significantly increased from 0.95% to 7.25% (ptrend <0.001 for both). In-hospital mortality significantly increased for IMV (31.5% in 2002 to 38.6% in 2014) recipients and decreased for patients requiring NIV (9.0% to 5.6%, ptrend <0.0001 for both). The average length of stay was nearly 7 days longer in the IMV group (12.2 days) and 2 days longer in the NIV group (6.8 days; p <0.001 for both). Hospital charges have nearly tripled for patients requiring IMV ($99,358 in 2014, ptrend <0.001) and doubled for those requiring NIV ($37,539 in 2014, ptrend <0.001). In conclusion, respiratory support strategies for patients with HF have significantly evolved with increasing use of NIV as compared with IMV. However, the in-hospital mortality associated with respiratory failure remains unacceptably high.

Original languageEnglish (US)
Pages (from-to)1712-1719
Number of pages8
JournalAmerican Journal of Cardiology
Issue number11
StatePublished - Dec 1 2019

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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