TY - JOUR
T1 - National Practice Patterns and Outcomes for T4b Urothelial Cancer of the Bladder
AU - Haque, Waqar
AU - Verma, Vivek
AU - Butler, E. Brian
AU - Teh, Bin S.
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/2
Y1 - 2018/2
N2 - The National Cancer Data Base was queried (2004-2013) for patients diagnosed with T4b bladder cancer. A total of 896 patients were observed. Patients treated with definitive chemoradiation or radical cystectomy were observed to have the highest overall survival. Purpose: Management of cT4b bladder cancer is poorly defined; national guidelines recommend chemotherapy (CT) alone or chemoradiation (CRT). Using a large, contemporary dataset, we evaluated national practice patterns as well as associated outcomes, especially with respect to radical cystectomy (RC) and CRT versus CT alone. Methods: The National Cancer Data Base was queried (2004-2013) for patients diagnosed with cT4bN0-3M0 bladder cancer. Patients were divided into 5 treatment groups: CT alone, CRT, RC (with/without CT/radiotherapy [RT]), other treatment (subtherapeutic RT with/without CT), or no treatment. Statistics included multivariable logistic regression to determine factors predictive of observation, Kaplan-Meier analysis to evaluate overall survival (OS), and Cox proportional hazards modeling to determine variables associated with OS. Results: Of 896 total patients, 185 (20.6%) underwent CT alone, 80 (8.9%) CRT, 161 (18.9%) RC, 221 (24.7%) other treatments, and 249 (27.8%) observation. Differences in treatment paradigms were appreciated based on age, gender, nodal status, insurance, and facility-related parameters. Observation yielded a median OS of 3.7 months, lower than CT alone (P <.001). As compared with the latter, CRT was associated with higher OS (10.5 vs. 12.1 months, P =.004). RC-based treatment displayed the numerically highest OS (14.2 months) and was statistically similar to CRT (P =.676). Treatment with any modality independently predicted for superior OS over observation. Conclusions: In the largest study of its kind, a surprisingly high proportion of patients underwent observation. CRT is associated with higher survival over CT alone, and carefully selected patients undergoing RC may experience prolonged survival.
AB - The National Cancer Data Base was queried (2004-2013) for patients diagnosed with T4b bladder cancer. A total of 896 patients were observed. Patients treated with definitive chemoradiation or radical cystectomy were observed to have the highest overall survival. Purpose: Management of cT4b bladder cancer is poorly defined; national guidelines recommend chemotherapy (CT) alone or chemoradiation (CRT). Using a large, contemporary dataset, we evaluated national practice patterns as well as associated outcomes, especially with respect to radical cystectomy (RC) and CRT versus CT alone. Methods: The National Cancer Data Base was queried (2004-2013) for patients diagnosed with cT4bN0-3M0 bladder cancer. Patients were divided into 5 treatment groups: CT alone, CRT, RC (with/without CT/radiotherapy [RT]), other treatment (subtherapeutic RT with/without CT), or no treatment. Statistics included multivariable logistic regression to determine factors predictive of observation, Kaplan-Meier analysis to evaluate overall survival (OS), and Cox proportional hazards modeling to determine variables associated with OS. Results: Of 896 total patients, 185 (20.6%) underwent CT alone, 80 (8.9%) CRT, 161 (18.9%) RC, 221 (24.7%) other treatments, and 249 (27.8%) observation. Differences in treatment paradigms were appreciated based on age, gender, nodal status, insurance, and facility-related parameters. Observation yielded a median OS of 3.7 months, lower than CT alone (P <.001). As compared with the latter, CRT was associated with higher OS (10.5 vs. 12.1 months, P =.004). RC-based treatment displayed the numerically highest OS (14.2 months) and was statistically similar to CRT (P =.676). Treatment with any modality independently predicted for superior OS over observation. Conclusions: In the largest study of its kind, a surprisingly high proportion of patients underwent observation. CRT is associated with higher survival over CT alone, and carefully selected patients undergoing RC may experience prolonged survival.
KW - Bladder cancer
KW - Chemoradiation
KW - Chemotherapy
KW - Cystectomy
KW - Radiation therapy
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U2 - 10.1016/j.clgc.2017.08.013
DO - 10.1016/j.clgc.2017.08.013
M3 - Article
AN - SCOPUS:85029692861
VL - 16
SP - 42-49.e1
JO - Clinical Genitourinary Cancer
JF - Clinical Genitourinary Cancer
SN - 1558-7673
IS - 1
ER -