Nasal carriage of inducible dormant and community-associated methicillin-resistant Staphylococcus aureus in an ambulatory population of predominantly university students

Gonzalo M.L. Bearman, Adriana E. Rosato, Susan Assanasen, Elizabeth A. Kleiner, Kara Elam, Cheryl Haner, Richard P. Wenzel

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Background: We studied risk factors for nasal colonization with inducible dormant methicillin-resistant Staphylococcus aureus (ID-MRSA) and community-associated MRSA (CA-MRSA) in a cohort of predominantly university students. Methods: Nasal surveillance cultures were performed in student health and ambulatory clinics. Molecular features were identified and risk factors for CA-MRSA and ID-MRSA colonization were determined by logistic regression. Results: Of the 1000 participants, 89% (n = 890) were university students. Sixty-four percent were female, 59% Caucasian. The mean age was 23.5 years; 1.6% (n = 16) were CA-MRSA and 1.4% (n = 14) were ID-MRSA colonized. Fifteen (94%) of the CA-MRSA strains were PFGE type IV. pvl (Panton-Valentine leukocidin gene) positivity was 75% in CA-MRSA and 57% in ID-MRSA. ID-MRSA isolates were pulsed-field gel electrophoresis (PFGE) type I, 7%; type II, 14%; type V, 7%; and type IV, 71%. CA-MRSA SCC. mec classification was 94% type IV and 6% type V. Risk factors for carriage of CA-MRSA were older age (OR 1.046, p= 0.040) and dog ownership (OR 1.450, p= 0.019). Single family home (OR 0.040, p= 0.007) was a protective factor. There were no significant variables of association found for ID-MRSA colonization. Conclusions: ID-MRSA/CA-MRSA colonization was low. Most isolates were PFGE types IV and II, pvl-positive and susceptible to several antibiotics. Older age and dog ownership were risk factors for CA-MRSA. Future studies are needed to assess the impact of ID-MRSA carriage.

Original languageEnglish (US)
Pages (from-to)e18-e24
JournalInternational Journal of Infectious Diseases
Volume14
Issue numberSUPPL. 3
DOIs
StatePublished - Sep 2010

Keywords

  • CA-MRSA
  • Epidemiology
  • ID-MRSA
  • Pathogenesis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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