Nanotechnology systems for drug delivery, multi-modal targeting and imaging of tumors

M. Singh, A. Patel, E. Lim, N. Zhang, K. Francis, R. Singh, S. Safe

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cancer is one of the leading causes of deaths (1.6 million deaths annually) in USA. Despite recent advances in chemotherapy, the survival rates in lung cancer patients are unsatisfactory due to limited efficiency of systemic or oral chemotherapy and associated side effects. Oral administration of anti-cancer agents presents a series of advantages for patients. However, most of these agents are hydrophobic and associated with low bioavailability. To overcome this issue we have designed: 1) a unique customized spray gun which allows simultaneously /pulsatile flow of two different liquid systems through single nozzle. This modification allowed us to formulate enteric coated SEDDS (E-SEDDS) of anticancer agents for oral delivery by using SEDDS as one liquid system and enteric coating solution as second liquid system. 2) Tumor homing nanoparticle of bio-imaging agents (D-Luciferin) will target tumor and enhance the time duration of imaging, which can be used for delivering therapeutics.

Original languageEnglish (US)
Title of host publicationTechnical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012
Pages346-349
Number of pages4
StatePublished - 2012
EventNanotechnology 2012: Advanced Materials, CNTs, Particles, Films and Composites - 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012 - Santa Clara, CA, United States
Duration: Jun 18 2012Jun 21 2012

Publication series

NameTechnical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012

Conference

ConferenceNanotechnology 2012: Advanced Materials, CNTs, Particles, Films and Composites - 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012
CountryUnited States
CitySanta Clara, CA
Period6/18/126/21/12

Keywords

  • Bioluminecence
  • Dual channel spray gun
  • In-vivo imaging
  • Multi-model tumor targeting
  • Self emulsified drug delivry

ASJC Scopus subject areas

  • Ceramics and Composites
  • Surfaces, Coatings and Films

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