TY - GEN
T1 - Nanotechnology systems for drug delivery, multi-modal targeting and imaging of tumors
AU - Singh, M.
AU - Patel, A.
AU - Lim, E.
AU - Zhang, N.
AU - Francis, K.
AU - Singh, R.
AU - Safe, S.
PY - 2012
Y1 - 2012
N2 - Cancer is one of the leading causes of deaths (1.6 million deaths annually) in USA. Despite recent advances in chemotherapy, the survival rates in lung cancer patients are unsatisfactory due to limited efficiency of systemic or oral chemotherapy and associated side effects. Oral administration of anti-cancer agents presents a series of advantages for patients. However, most of these agents are hydrophobic and associated with low bioavailability. To overcome this issue we have designed: 1) a unique customized spray gun which allows simultaneously /pulsatile flow of two different liquid systems through single nozzle. This modification allowed us to formulate enteric coated SEDDS (E-SEDDS) of anticancer agents for oral delivery by using SEDDS as one liquid system and enteric coating solution as second liquid system. 2) Tumor homing nanoparticle of bio-imaging agents (D-Luciferin) will target tumor and enhance the time duration of imaging, which can be used for delivering therapeutics.
AB - Cancer is one of the leading causes of deaths (1.6 million deaths annually) in USA. Despite recent advances in chemotherapy, the survival rates in lung cancer patients are unsatisfactory due to limited efficiency of systemic or oral chemotherapy and associated side effects. Oral administration of anti-cancer agents presents a series of advantages for patients. However, most of these agents are hydrophobic and associated with low bioavailability. To overcome this issue we have designed: 1) a unique customized spray gun which allows simultaneously /pulsatile flow of two different liquid systems through single nozzle. This modification allowed us to formulate enteric coated SEDDS (E-SEDDS) of anticancer agents for oral delivery by using SEDDS as one liquid system and enteric coating solution as second liquid system. 2) Tumor homing nanoparticle of bio-imaging agents (D-Luciferin) will target tumor and enhance the time duration of imaging, which can be used for delivering therapeutics.
KW - Bioluminecence
KW - Dual channel spray gun
KW - In-vivo imaging
KW - Multi-model tumor targeting
KW - Self emulsified drug delivry
UR - http://www.scopus.com/inward/record.url?scp=84864968828&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864968828&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84864968828
SN - 9781466562745
T3 - Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012
SP - 346
EP - 349
BT - Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012
T2 - Nanotechnology 2012: Advanced Materials, CNTs, Particles, Films and Composites - 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012
Y2 - 18 June 2012 through 21 June 2012
ER -