Nanotechnologies for biomolecular detection and medical diagnostics

Mark Ming Cheng Cheng, Giovanni Cuda, Yuri L. Bunimovich, Marco Gaspari, James R. Heath, Haley D. Hill, Chad A. Mirkin, A. Jasper Nijdam, Rosa Terracciano, Thomas Thundat, Mauro Ferrari

Research output: Contribution to journalReview articlepeer-review

420 Scopus citations


Nanotechnology-based platforms for the high-throughput, multiplexed detection of proteins and nucleic acids in heretofore unattainable abundance ranges promise to bring substantial advances in molecular medicine. The emerging approaches reviewed in this article, with reference to their diagnostic potential, include nanotextured surfaces for proteomics, a two-particle sandwich assay for the biological amplification of low-concentration biomolecular signals, and silicon-based nanostructures for the transduction of molecular binding into electrical and mechanical signals, respectively.

Original languageEnglish (US)
Pages (from-to)11-19
Number of pages9
JournalCurrent Opinion in Chemical Biology
Issue number1
StatePublished - Feb 2006

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


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